English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Identification and functional characterization of de novo FOXP1 variants in cases of autism, intellectual disability and language impairment.

Sollis, E., Vino, A., Gilissen, C., Frohlich, H., Graham, S. A., Pfundt, R., et al. (2015). Identification and functional characterization of de novo FOXP1 variants in cases of autism, intellectual disability and language impairment. Poster presented at American Society for Human Genetics Annual Meeting, Baltimore, US.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-D1C4-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-6DAB-2
Genre: Poster

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Sollis, Elliot1, Author              
Vino, Arianna1, Author              
Gilissen, Christian2, Author
Frohlich, Henning3, Author
Graham, Sarah A.1, Author              
Pfundt, Rolph4, Author
Dimitropoulou, Danai1, Author              
Brunner, Han2, 4, Author
Rappold, Gudrun2, Author
Fisher, Simon E.1, Author              
Derizioti, Pelagia1, Author              
Affiliations:
1Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
2Department of Human Genetics, Radboud Institute for Molecular Life Sciences and Donders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
3Department of Molecular Human Genetics, Ruprecht-Karls-University, Heidelberg, Germany, ou_persistent22              
4Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, the Netherlands, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Heterozygous variants disrupting the FOXP1 transcription factor (forkhead box protein P1; OMIM 605515) have been implicated in an emerging syndrome of global developmental delay, intellectual disability and autistic features (OMIM 613670). All etiological FOXP1 variants reported to date have been de novo, and include whole gene deletions, translocations, nonsense variants, missense variants and frameshift variants. Speech and language impairments, which range from moderate to severe and affect expressive language to a higher degree than receptive language, are also consistently reported in individuals carrying FOXP1 variants. The presence of speech and language deficits in this FOXP1-deficiency syndrome is of particular interest, because FOXP1 is the closest paralogous gene to FOXP2 (OMIM 605317), which is disrupted in a rare form of speech and language disorder (OMIM 602081). In this study, we report three novel heterozygous de novo FOXP1 variants identified through clinical whole-exome sequencing in individuals diagnosed with intellectual disability and/or autism spectrum disorders. We performed detailed functional characterization of the three novel variants found here alongside three previously detected de novo etiological variants. Our assays examined the effects of the six de novo FOXP1 variants on several aspects of protein function, including subcellular localization and transcriptional repression capability. In addition, because FOXP1 and FOXP2 are both expressed in the striatum where they may interact with the potential to co-regulate downstream targets, we investigated the effects of the six de novo FOXP1 variants on FOXP1-FOXP2 interactions. Our findings provide further insight into the pathogenic mechanisms of FOXP1-deficiency syndrome, and highlight the value of combining clinical exome sequencing with functional analyses in understanding the molecular basis of neurodevelopmental disorders.

Details

show
hide
Language(s): eng - English
 Dates: 2015
 Publication Status: Not specified
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: -
 Degree: -

Event

show
hide
Title: American Society for Human Genetics Annual Meeting
Place of Event: Baltimore, US
Start-/End Date: 2015-10-06 - 2015-10-10

Legal Case

show

Project information

show

Source

show