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  Low-frequency transcranial magnetic stimulation over left dorsal premotor cortex improves the dynamic control of visuospatially cued actions

Ward, N. S., Bestmann, S., Hartwigsen, G., Weiss, M. M., Christensen, L. O. D., Frackowiak, R. S. J., et al. (2010). Low-frequency transcranial magnetic stimulation over left dorsal premotor cortex improves the dynamic control of visuospatially cued actions. The Journal of Neuroscience, 30(27), 9216-9223. doi:10.1523/JNEUROSCI.4499-09.2010.

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 Creators:
Ward, Nick S.1, Author
Bestmann, Sven1, 2, Author
Hartwigsen, Gesa3, Author           
Weiss, Michael M.3, Author
Christensen, Lars O. D.1, Author
Frackowiak, Richard S. J.2, 4, Author
Rothwell, John C.1, Author
Siebner, Hartwig R.3, 5, Author
Affiliations:
1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
2Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
3Department of Neurology, Christian Albrecht University Kiel, Germany, ou_persistent22              
4Service de Neurologie, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              

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 Abstract: Left rostral dorsal premotor cortex (rPMd) and supramarginal gyrus (SMG) have been implicated in the dynamic control of actions. In 12 right-handed healthy individuals, we applied 30 min of low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) over left rPMd to investigate the involvement of left rPMd and SMG in the rapid adjustment of actions guided by visuospatial cues. After rTMS, subjects underwent functional magnetic resonance imaging while making spatially congruent button presses with the right or left index finger in response to a left- or right-sided target. Subjects were asked to covertly prepare motor responses as indicated by a directional cue presented 1 s before the target. On 20% of trials, the cue was invalid, requiring subjects to readjust their motor plan according to the target location. Compared with sham rTMS, real rTMS increased the number of correct responses in invalidly cued trials. After real rTMS, task-related activity of the stimulated left rPMd showed increased task-related coupling with activity in ipsilateral SMG and the adjacent anterior intraparietal area (AIP). Individuals who showed a stronger increase in left-hemispheric premotor–parietal connectivity also made fewer errors on invalidly cued trials after rTMS. The results suggest that rTMS over left rPMd improved the ability to dynamically adjust visuospatial response mapping by strengthening left-hemispheric connectivity between rPMd and the SMG–AIP region. These results support the notion that left rPMd and SMG–AIP contribute toward dynamic control of actions and demonstrate that low-frequency rTMS can enhance functional coupling between task-relevant brain regions and improve some aspects of motor performance.

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Language(s): eng - English
 Dates: 2010-07-07
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1523/JNEUROSCI.4499-09.2010
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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Pages: - Volume / Issue: 30 (27) Sequence Number: - Start / End Page: 9216 - 9223 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187