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  Alpha-synuclein levels in blood plasma decline with healthy aging.

Koehler, N. K. U., Stransky, E., Meyer, M., Gaertner, S., Shing, M., Schnaldt, M., et al. (2015). Alpha-synuclein levels in blood plasma decline with healthy aging. PLOS One, 10(4): e0123444. doi:10.1371/journal.pone.0123444.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-DB9E-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6EFB-F
Genre: Journal Article

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Koehler, N. K. U., Author
Stransky, E., Author
Meyer, M., Author
Gaertner, S., Author
Shing, M., Author
Schnaldt, M., Author
Celej, M. S., Author
Jovin, T. M.1, Author              
Leyhe, T., Author
Laske, C., Author
Batra, A., Author
Buchkremer, G., Author
Fallgatter, A. J., Author
Wernet, D., Author
Richartz-Salzburger, E., Author
Affiliations:
1Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society, ou_578629              

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 Abstract: There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF, blood serum and plasma. Considering key events of aging that include proteostasis, alpha-synuclein may not only be useful as a marker for differential diagnosis but also for aging per se. To explore this hypothesis, we developed a highly specific ELISA to measure alpha-synuclein. In healthy males plasma alpha-synuclein levels correlated strongly with age, revealing much lower concentrations in older (avg. 58.1 years) compared to younger (avg. 27.6 years) individuals. This difference between the age groups was enhanced after acidification of the plasmas (p<0.0001), possibly reflecting a decrease of alpha-synuclein-antibody complexes or chaperone activity in older individuals. Our results support the concept that alpha-synuclein homeostasis may be impaired early on, possibly due to disturbance of the proteostasis network, a key component of healthy aging. Thus, alpha-synuclein may be a novel biomarker of aging, a factor that should be considered when analyzing its presence in biological specimens.

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Language(s): eng - English
 Dates: 2015-04-06
 Publication Status: Published online
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0123444
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Title: PLOS One
Source Genre: Journal
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Pages: 16 Volume / Issue: 10 (4) Sequence Number: e0123444 Start / End Page: - Identifier: -