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  Assessing intracortical myelin in the living human brain using myelinated cortical thickness

Rowley, C. D., Bazin, P.-L., Tardif, C., Sehmbi, M., Hashim, E., Zaharieva, N., et al. (2015). Assessing intracortical myelin in the living human brain using myelinated cortical thickness. Frontiers in Neuroscience, 9: 396. doi:10.3389/fnins.2015.00396.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-DC55-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-776C-F
Genre: Journal Article

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 Creators:
Rowley, Christopher D.1, Author
Bazin, Pierre-Louis2, 3, Author              
Tardif, Christine3, Author              
Sehmbi, Manpreet4, Author
Hashim, Eyesha1, Author
Zaharieva, Nadejda 1, Author
Frey, Benicio4, Author
Minuzzi, Lucianno4, Author
Bock, Nicholas A.1, Author
Affiliations:
1Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, ON, Canada, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada, ou_persistent22              

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Free keywords: Cerebral Cortex, myelin, Magnetic Resonance Imaging, Bipolar Disorder, cortical thickness
 Abstract: Alterations in the myelination of the cerebral cortex may underlie abnormal cortical function in a variety of brain diseases. Here, we describe a technique for investigating changes in intracortical myelin in clinical populations on the basis of cortical thickness measurements with magnetic resonance imaging (MRI) at 3 Tesla. For this, we separately compute the thickness of the shallower, lightly myelinated portion of the cortex and its deeper, heavily myelinated portion (referred to herein as unmyelinated and myelinated cortex respectively). Our expectation is that the thickness of the myelinated cortex will be a specific biomarker for disruptions in myeloarchitecture. We show representative atlases of total cortical thickness, T, unmyelinated cortical thickness, G, and myelinated cortical thickness, M, for a healthy group of 20 female subjects. We further demonstrate myelinated cortical thickness measurements in a preliminary clinical study of 10 bipolar disorder type-I subjects and 10 healthy controls, and report significant decreases in the middle frontal gyrus in T, G, and M in the disorder, with the largest percentage change occurring in M. This study highlights the potential of myelinated cortical thickness measurements for investigating intracortical myelin involvement in brain disease at clinically relevant field strengths and resolutions.

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Language(s): eng - English
 Dates: 2015-08-122015-10-082015-10-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnins.2015.00396
PMID: 26557052
PMC: PMC4615825
Other: eCollection 2015
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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 9 Sequence Number: 396 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548