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  Toxoplasma gondii myosins B/C: one gene, two tails, two localizations and a role in parasite division

Delbac, F., Sänger, A., Neuhaus, E. M., Stratmann, R., Ajioka, J. W., Toursel, C., et al. (2001). Toxoplasma gondii myosins B/C: one gene, two tails, two localizations and a role in parasite division. The Journal of Cell Biology: JCB, 155(4), 613-623. doi:10.1083/jcb.200012116.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-E624-2 Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-E625-F
Genre: Zeitschriftenartikel
Alternativer Titel : Toxoplasma gondii myosins B/C: one gene, two tails, two localizations and a role in parasite division

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JCellBiol_155_2001_613.pdf (beliebiger Volltext), 691KB
 
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http://www.jcb.org/cgi/reprint/155/4/613 (beliebiger Volltext)
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http://dx.doi.org/10.1083/jcb.200012116 (beliebiger Volltext)
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Urheber

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 Urheber:
Delbac, Frédéric, Autor
Sänger, Astrid, Autor
Neuhaus, Eva Maria1, Autor              
Stratmann, Rolf, Autor
Ajioka, James W., Autor
Toursel, Catherine, Autor
Herm-Götz, Angelika, Autor
Tomavo, Stanisla, Autor
Soldati, Thierry2, Autor              
Soldati, Dominique, Autor
Affiliations:
1Department of Molecular Cell Research, Max Planck Institute for Medical Research, Max Planck Society, ou_1497703              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

Inhalt

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Schlagwörter: Apicomplexa; unconventional myosin XIV; localization; Toxoplasma gondii; cell division
 Zusammenfassung: In apicomplexan parasites, actin-disrupting drugs and the inhibitor of myosin heavy chain ATPase, 2,3-butanedione monoxime, have been shown to interfere with host cell invasion by inhibiting parasite gliding motility. We report here that the actomyosin system of Toxoplasma gondii also contributes to the process of cell division by ensuring accurate budding of daughter cells. T. gondii myosins B and C are encoded by alternatively spliced mRNAs and differ only in their COOH-terminal tails. MyoB and MyoC showed distinct subcellular localizations and dissimilar solubilities, which were conferred by their tails. MyoC is the first marker selectively concentrated at the anterior and posterior polar rings of the inner membrane complex, structures that play a key role in cell shape integrity during daughter cell biogenesis. When transiently expressed, MyoB, MyoC, as well as the common motor domain lacking the tail did not distribute evenly between daughter cells, suggesting some impairment in proper segregation. Stable overexpression of MyoB caused a significant defect in parasite cell division, leading to the formation of extensive residual bodies, a substantial delay in replication, and loss of acute virulence in mice. Altogether, these observations suggest that MyoB/C products play a role in proper daughter cell budding and separation.

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Sprache(n): eng - Englisch
 Datum: 2001-09-282000-12-282001-10-052001-11-122001-11-12
 Publikationsstatus: Im Druck publiziert
 Seiten: 11
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Art des Abschluß: -

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Quelle 1

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Titel: The Journal of Cell Biology : JCB
  Andere : J. Cell Biol.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York, NY : Rockefeller Institute Press
Seiten: - Band / Heft: 155 (4) Artikelnummer: - Start- / Endseite: 613 - 623 Identifikator: ISSN: 0021-9525
CoNE: /journals/resource/991042742946024