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  Mutations of the EPHB6 receptor tyrosine kinase induce a pro-metastatic phenotype in non-small cell lung cancer

Bulk, E., Yu, J., Hascher, A., Koschmieder, S., Wiewrodt, R., Krug, U., et al. (2012). Mutations of the EPHB6 receptor tyrosine kinase induce a pro-metastatic phenotype in non-small cell lung cancer. PLoS One, 7(12): e44591. doi:10.1371/journal.pone.0044591.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-E6EA-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-E6F8-6
Genre: Journal Article

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 Creators:
Bulk, Etmar , Author
Yu, Jun, Author
Hascher, Antje, Author
Koschmieder, Steffen , Author
Wiewrodt, Rainer , Author
Krug, Utz, Author
Timmermann, Bernd1, Author              
Marra, Alessandro , Author
Hillejan, Ludger , Author
Wiebe, Karsten, Author
Berdel, Wolfgang E. , Author
Schwab, Albrecht, Author
Müller-Tidow, Carsten , Author
Affiliations:
1Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: Alterations of Eph receptor tyrosine kinases are frequent events in human cancers. Genetic variations of EPHB6 have been described but the functional outcome of these alterations is unknown. The current study was conducted to screen for the occurrence and to identify functional consequences of EPHB6 mutations in non-small cell lung cancer. Here, we sequenced the entire coding region of EPHB6 in 80 non-small cell lung cancer patients and 3 tumor cell lines. Three potentially relevant mutations were identified in primary patient samples of NSCLC patients (3.8%). Two point mutations led to instable proteins. An in frame deletion mutation (del915-917) showed enhanced migration and accelerated wound healing in vitro. Furthermore, the del915-917 mutation increased the metastatic capability of NSCLC cells in an in vivo mouse model. Our results suggest that EPHB6 mutations promote metastasis in a subset of patients with non-small cell lung cancer.

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Language(s): eng - English
 Dates: 2012-12-04
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
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 Identifiers: DOI: 10.1371/journal.pone.0044591
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (12) Sequence Number: e44591 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850