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  Involvement of the MLL gene in adult T-lymphoblastic leukemia

Türkmen, S., Timmermann, B., Bartels, G., Gröger, D., Meyer, C., Schwartz, S., et al. (2012). Involvement of the MLL gene in adult T-lymphoblastic leukemia. Genes, Chromosomes and Cancer, 51(12), 1114-1124. doi:10.1002/gcc.21996.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-E6F5-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-E6F6-A
Genre: Journal Article

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Türkmen, Seval , Author
Timmermann, Bernd1, Author              
Bartels, Gesine , Author
Gröger, Daniela , Author
Meyer, Claus, Author
Schwartz, Stefan , Author
Haferlach, Claudia , Author
Rieder, Harald , Author
Gökbuget, Nicola , Author
Hoelzer, Dieter , Author
Marschalek, Rolf , Author
Burmeister, Thomas, Author
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1Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: While the MLL “recombinome” is relatively well characterized in B-cell precursor acute lymphoblastic leukemia (BCP ALL), available data for adult acute T-lymphoblastic leukemia (T-ALL) are scarce. We performed fluorescence in situ hybridization (FISH) for an MLL split signal on 223 adult T-ALL samples obtained within the framework of the German Multicenter ALL 07/2003 therapy trial. Three biphenotypic leukemias (T-ALL/AML) were also included in the analysis. Samples showing any alteration by FISH were further investigated to characterize the MLL aberration. In addition, they were investigated for common genetic lesions known in T-ALL. Twenty-two cases (9.5%) showed an abnormal MLL signal by FISH analysis. Most of these appeared to be deletions or gains but in five cases (2.1%) a chromosomal translocation involving the MLL gene was identified. The translocation partners and chromosomal breakpoints were molecularly characterized. Three T-ALLs had an MLL-AF6/t(6;11) and two biphenotypic leukemias had an MLL-ELL/t(11;19). The chromosomal breakpoints in two of the MLL-AF6-positive cases were located outside the classical MLL major breakpoint cluster known from BCP ALL. In conclusion, the spectrum of MLL translocation partners in adult T-ALL much more resembles that of AML than that of BCP ALL and thus the mechanisms by which MLL contributes to leukemogenesis in adult T-ALL appear to differ from those in BCP ALL. Proposals are made for the diagnostic assessment of MLL fusion genes in adult T-ALL.

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Language(s): eng - English
 Dates: 2012-08-252012-12
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/gcc.21996
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Title: Genes, Chromosomes and Cancer
Source Genre: Journal
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Publ. Info: New York, N.Y. : Wiley-Liss, Inc.
Pages: - Volume / Issue: 51 (12) Sequence Number: - Start / End Page: 1114 - 1124 Identifier: ISSN: 1045-2257
CoNE: /journals/resource/954925590417