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  Coherent dynamics in networks of single protein molecules

Lerch, H. P., Stange, P., Mikhailov, A. S., & Hess, B. (2000). Coherent dynamics in networks of single protein molecules. Recent research developments in biophysical chemistry, 1, 41-59. Retrieved from http://cat.inist.fr/?aModele%3DafficheN%26cpsidt%3D14194575.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-F4A6-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-F4A7-D
Genre: Journal Article
Alternative Title : Coherent dynamics in networks of single protein molecules

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RecentResDevelopBiophysChem_1_2000_41.pdf (Any fulltext), 3MB
 
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 Creators:
Lerch, Hans Peter, Author
Stange, Pedro1, Author              
Mikhailov, Alexander S., Author
Hess, Benno2, Author              
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              
2Emeritus Group Prof. Dr. B. Hess, Max Planck Institute for Medical Research, Max Planck Society, ou_1497713              

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 Abstract: Enzymes are single-molecule catalysts representing chemical protein machines. We show that enzymic reactions in small spatial volumes, characteristic for a living biological cell, may proceed in a special kinetic regime of a molecular network. In this regime the enzymic population behaves like a network of communicating machines. When interactions between the machines are sufficiently intensive, strong correlations between intramolecular dynamics of individual machines in the network can emerge. Thus, mutual synchronization of enzymic turnover cycles develops. The theoretical analysis, which has been performed for allosteric product-activated and product-inhibited reactions, as well for the non-allosteric reactions with substrate loops, show that coherent intramolecular dynamics is a robust phenomenon, which persists even when significant intramolecular fluctuations are present.

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Language(s): eng - English
 Dates: 2000
 Publication Status: Published in print
 Pages: 19
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666224
URI: http://cat.inist.fr/?aModele%3DafficheN%26cpsidt%3D14194575
Other: 4971
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Title: Recent research developments in biophysical chemistry
  Alternative Title : Recent. Res. Devel. Biophys. Chem.
Source Genre: Book
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Publ. Info: Trivandrum : Transworld Research Network
Pages: - Volume / Issue: 1 Sequence Number: - Start / End Page: 41 - 59 Identifier: ISBN: 81-86846-90-5