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  Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb

Margrie, T. W., Sakmann, B., & Urban, N. N. (2001). Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb. Proceedings of the National Academy of Sciences of the United States of America, 98(1), 319-324. doi:10.1073/pnas.011523098.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-FB54-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-FB55-F
Genre: Journal Article
Alternative Title : Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb

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PNAS_98_ 2001_319.pdf (Any fulltext), 208KB
 
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 Creators:
Margrie, Troy W.1, 2, Author              
Sakmann, Bert1, Author              
Urban, Nathaniel N.1, Author              
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: In the mammalian main olfactory bulb (MOB), the release of glutamate from lateral dendrites of mitral cells onto the dendrites of granule cells evokes recurrent and lateral inhibition of mitral cell activity. Whole-cell voltage recordings in the mouse MOB in vivo and in vitro show that recurrent and lateral inhibition together control the number, duration, and onset of odor-evoked action potential (AP) firing in mitral cells. APs in mitral cells propagate into the lateral dendrites and evoke a transient increase in dendritic calcium concentration ([Ca2+]), which is decremental with distance from the soma, and increases with AP number. These results suggest that the extent of AP propagation in lateral dendrites of mitral cells, along with the concomitant dendritic Ca(2+) transient, controls the amplitude of lateral and recurrent inhibition and thus is a critical determinant of odor-specific AP patterns in the MOB.

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Language(s): eng - English
 Dates: 20002000-11-022001-01-02
 Publication Status: Published in print
 Pages: 6
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 Table of Contents: -
 Rev. Method: Peer
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Natl. Acad. Sci. USA
Source Genre: Journal
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Publ. Info: Washington, DC : National Academy of Sciences
Pages: - Volume / Issue: 98 (1) Sequence Number: - Start / End Page: 319 - 324 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230