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  AMPA receptor channels with long-lasting desensitization in bipolar interneurons contribute to synaptic depression in a novel feedback circuit in layer 2/3 of rat neocortex

Rozov, A., Jerecic, J., Sakmann, B., & Burnashev, N. (2001). AMPA receptor channels with long-lasting desensitization in bipolar interneurons contribute to synaptic depression in a novel feedback circuit in layer 2/3 of rat neocortex. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 21(20), 8062-8071. doi:0270-6474/01/218062.

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Alternativer Titel : AAMPA receptor channels with long-lasting desensitization in bipolar interneurons contribute to synaptic depression in a novel feedback circuit in layer 2/3 of rat neocortex

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JNeurosci_21_2001_8062.pdf (beliebiger Volltext), 452KB
 
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 Urheber:
Rozov, Andrej1, 2, Autor           
Jerecic, Jasna2, Autor           
Sakmann, Bert1, Autor           
Burnashev, Nail1, Autor           
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Schlagwörter: neocortex; interneurons; neuronal circuit; synaptic depression; AMPA receptors; desensitization
 Zusammenfassung: A novel, local inhibitory circuit in layer 2/3 of rat somatosensory cortex is described that connects pyramidal cells reciprocally with GABAergic vasoactive intestinal polypeptide-immunoreactive bipolar interneurons. In paired whole-cell recordings, the glutamatergic unitary responses (EPSPs or EPSCs) in bipolar cells evoked by repetitive (10 Hz) stimulation of a pyramidal cell show strong frequency-dependent depression. Unitary IPSPs evoked in pyramidal cells by repetitive stimulation of bipolar cells, on average, maintained their amplitude. This suggests that the excitatory synapses on bipolar cells act as a low-pass filter in the reciprocal pyramid-to-bipolar circuit. The EPSCs in bipolar cells are mediated predominantly by AMPA receptor (AMPAR) channels. AMPARs desensitize rapidly and recover slowly from desensitization evoked by a brief pulse of glutamate. In slices, reduction of AMPAR desensitization by cyclothiazide (50-100 microm) or conditioning steady-state desensitization induced by application of extracellular AMPA (50 nm) or glutamate (50 microm) strongly reduced synaptic depression. It is concluded that in the local circuits between pyramidal and bipolar cells the desensitization of AMPARs in bipolar cells contributes to low-pass feedback inhibition of layer 2/3 pyramidal neurons by bipolar cells.

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Sprache(n): eng - English
 Datum: 2001-08-062000-12-222001-08-082001-10-15
 Publikationsstatus: Erschienen
 Seiten: 10
 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: Expertenbegutachtung
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Titel: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Andere : J. Neurosci.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Baltimore, MD : The Society
Seiten: - Band / Heft: 21 (20) Artikelnummer: - Start- / Endseite: 8062 - 8071 Identifikator: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1