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  Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7

Sansig, G., Bushell, T. J., Clarke, V. R. J., Rozov, A., Burnashev, N., Portet, C., et al. (2001). Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 21(22), 8734-8745. doi:0270-6474/01/218734-12.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-FFA1-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-FFA2-1
Genre: Journal Article
Alternative Title : Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7

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JNeurosci_21_2001_8734.pdf (Any fulltext), 350KB
 
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 Creators:
Sansig, Gilles, Author
Bushell, Trevor J., Author
Clarke, Vernon R. J., Author
Rozov, Andrej1, 2, Author              
Burnashev, Nail1, Author              
Portet, Chantal, Author
Gasparini, Fabrizio, Author
Schmutz, Markus, Author
Klebs, Klaus, Author
Shigemoto, Ryuichi, Author
Flor, Peter J., Author
Kuhn, Rainer, Author
Knoepfel, Thomas, Author
Schroeder, Markus, Author
Hampson, David R., Author
Collett, Valerie J., Author
Zhang, Congxiao, Author
Duvoisin, Robert M., Author
Collingridge, Graham L., Author
van der Putten, Herman, Author
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: epilepsy; mGluR7; knock-out; mice; group III mGluR; (R,S)-4-phosphonophenylglycine
 Abstract: To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7(-/-)). After the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype, we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals aged 12 weeks and older, subthreshold doses of these drugs induced seizures in mGluR7(-/-), but not in mGluR7(+/-), mice. PTZ-induced seizures were inhibited by three standard anticonvulsant drugs, but not by the group III selective mGluR agonist (R,S)-4-phosphonophenylglycine (PPG). Consistent with the lack of signs of epileptic activity in the absence of specific stimuli, mGluR7(-/-) mice showed no major changes in synaptic properties in two slice preparations. However, slightly increased excitability was evident in hippocampal slices. In addition, there was slower recovery from frequency facilitation in cortical slices, suggesting a role for mGluR7 as a frequency-dependent regulator in presynaptic terminals. Our findings suggest that mGluR7 receptors have a unique role in regulating neuronal excitability and that these receptors may be a novel target for the development of anticonvulsant drugs.

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Language(s): eng - English
 Dates: 2001-04-092001-09-052001-11-15
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 21 (22) Sequence Number: - Start / End Page: 8734 - 8745 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1