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  Functional classification of memory CD8(+) T cells by CX(3)CR1 expression

Böttcher, J. P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Höchst, B., et al. (2015). Functional classification of memory CD8(+) T cells by CX(3)CR1 expression. NATURE COMMUNICATIONS, 6: 8306. doi:10.1038/ncomms9306.

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 Creators:
Böttcher, Jan P.1, Author
Beyer, Marc1, Author
Meissner, Felix2, Author              
Abdullah, Zeinab1, Author
Sander, Jil1, Author
Höchst, Bastian1, Author
Eickhoff, Sarah1, Author
Rieckmann, Jan C.3, Author              
Russo, Caroline1, Author
Bauer, Tanja1, Author
Flecken, Tobias1, Author
Giesen, Dominik1, Author
Engel, Daniel1, Author
Jung, Steffen1, Author
Busch, Dirk H.1, Author
Protzer, Ulrike1, Author
Thimme, Robert1, Author
Mann, Matthias1, Author
Kurts, Christian1, Author
Schultze, Joachim L.1, Author
Kastenmüller, Wolfgang1, AuthorKnolle, Percy A.1, Author more..
Affiliations:
1external, ou_persistent22              
2Meissner, Felix / Experimental Systems Immunology, Max Planck Institute of Biochemistry, Max Planck Society, ou_2149678              
3Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: CHRONIC VIRAL-INFECTION; FRACTALKINE RECEPTOR CX(3)CR1; DENDRITIC CELLS; LYMPH-NODES; NETWORK VISUALIZATION; SELECTIVE EXPRESSION; LINEAGE RELATIONSHIP; TRANSCRIPTION FACTOR; PROTECTIVE IMMUNITY; IL-7 RECEPTOR
 Abstract: Localization of memory CD8(+) T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX(3)CR1 distinguishes memory CD8(+) T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX(3)CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8(+) T cells with effector function. We find CD62L(hi)CX(3)CR1(+) memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX(3)CR1(+) memory CD8(+) T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3CR1-based functional classification will help to resolve the principles of protective CD8(+) T-cell memory.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published online
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000363020100010
DOI: 10.1038/ncomms9306
 Degree: -

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Title: NATURE COMMUNICATIONS
Source Genre: Journal
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Publ. Info: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 6 Sequence Number: 8306 Start / End Page: - Identifier: ISSN: 2041-1723