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  Genome-wide patterns of selection in 230 ancient Eurasians

Mathieson, I., Lazaridis, I., Rohland, N., Mallick, S., Patterson, N., Roodenberg, S. A., et al. (2015). Genome-wide patterns of selection in 230 ancient Eurasians. Nature, 528(7583): 16152, pp. 499-503. doi:10.1038/nature16152.

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 Creators:
Mathieson, Iain, Author
Lazaridis, Iosif, Author
Rohland, Nadin, Author
Mallick, Swapan, Author
Patterson, Nick, Author
Roodenberg, Songül Alpaslan, Author
Harney, Eadaoin, Author
Stewardson, Kristin, Author
Fernandes, Daniel, Author
Novak, Mario, Author
Sirak, Kendra, Author
Gamba, Cristina, Author
Jones, Eppie R., Author
Llamas, Bastien, Author
Dryomov, Stanislav, Author
Pickrell, Joseph, Author
Arsuaga, Juan Luís, Author
de Castro, José María Bermúdez, Author
Carbonell, Eudald, Author
Gerritsen, Fokke, Author
Khokhlov, Aleksandr, AuthorKuznetsov, Pavel, AuthorLozano, Marina, AuthorMeller, Harald, AuthorMochalov, Oleg, AuthorMoiseyev, Vyacheslav, AuthorGuerra, Manuel A. Rojo, AuthorRoodenberg, Jacob, AuthorVergès, Josep Maria, AuthorKrause, Johannes1, Author           Cooper, Alan, AuthorAlt, Kurt W., AuthorBrown, Dorcas, AuthorAnthony, David, AuthorLalueza-Fox, Carles, AuthorHaak, Wolfgang1, Author           Pinhas, Ron, AuthorReich, David, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, Kahlaische Str. 10, 07745 Jena, DE, ou_2074310              

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Free keywords: Evolutionary genetics, Genomics, Population genetics
 Abstract: Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe’s first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 bc, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.

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Language(s): eng - English
 Dates: 2015-03-122015-10-302015-11-232015-12-24
 Publication Status: Issued
 Pages: 16
 Publishing info: -
 Table of Contents: Genome-wide ancient DNA from West Eurasia
Insight into population transformations
Twelve signals of selection
Evidence of selection on height
Future studies of selection with ancient DNA
Methods
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nature16152
Other: shh241
 Degree: -

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
 Creator(s):
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 528 (7583) Sequence Number: 16152 Start / End Page: 499 - 503 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238