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  Whole-brain in-vivo measurements of the axonal g-ratio in a group of 37 healthy volunteers

Mohammadi, S., Carey, D., Dick, F., Diedrichsen, J., Sereno, M. I., Reisert, M., et al. (2015). Whole-brain in-vivo measurements of the axonal g-ratio in a group of 37 healthy volunteers. Frontiers in Neuroscience, 9: 441. doi:10.3389/fnins.2015.00441.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-0E7E-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-5F52-7
Genre: Journal Article

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 Creators:
Mohammadi, Siawoosh1, 2, Author
Carey, Daniel3, Author
Dick, Fred3, Author
Diedrichsen, Joern4, Author
Sereno, Martin I.3, Author
Reisert, Marco5, Author
Callaghan, Martina F.5, Author
Weiskopf, Nikolaus5, 6, Author              
Affiliations:
1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
2Birkbeck-UCL Centre for Neuroimaging, London, United Kingdom, ou_persistent22              
3Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
4Department of Radiology, University Medical Center, Freiburg, Germany, ou_persistent22              
5Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: Magnetization transfer imaging; G-ratio; In-vivo histology; Myelin volume fraction; Fiber volume fraction; Diffusion MRI; DTI; Multi-parameter mapping
 Abstract: The g-ratio, quantifying the ratio between the inner and outer diameters of a fiber, is an important microstructural characteristic of fiber pathways and is functionally related to conduction velocity. We introduce a novel method for estimating the MR g-ratio non-invasively across the whole brain using high-fidelity magnetization transfer (MT) imaging and single-shell diffusion MRI. These methods enabled us to map the MR g-ratio in vivo across the brain’s prominent fiber pathways in a group of 37 healthy volunteers and to estimate the inter-subject variability. Effective correction of susceptibility-related distortion artifacts was essential before combining the MT and diffusion data, in order to reduce partial volume and edge artifacts. The MR g-ratio is in good qualitative agreement with histological findings despite the different resolution and spatial coverage of MRI and histology. The MR g-ratio holds promise as an important non-invasive biomarker due to its microstructural and functional relevance in neurodegeneration.

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Language(s): eng - English
 Dates: 2015-08-272015-11-032015-11-27
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnins.2015.00441
PMID: 26640427
PMC: PMC4661323
Other: eCollection 2015
 Degree: -

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Project name : Non-invasive in vivo histology in health and disease using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Funding program : FP7 (ERC-2013-CoG)
Funding organization : European Research Council
Project name : -
Grant ID : 091593/Z/10/Z
Funding program : -
Funding organization : Wellcome Trust (WT)
Project name : -
Grant ID : MO 2397/1-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 9 Sequence Number: 441 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548