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  Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging

Kiryutin, A. S., Zimmermann, H., Yurkovskaya, A. V., Vieth, H.-M., & Ivanov, K. L. (2015). Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging. Journal of Magnetic Resonance, 261, 64-72. doi:10.1016/j.jmr.2015.10.004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-19A0-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-19A1-C
Genre: Journal Article

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Kiryutin, Alexey S., Author
Zimmermann, Herbert1, Author              
Yurkovskaya, Alexandra V., Author
Vieth, Hans-Martin, Author
Ivanov, Konstantin L., Author
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1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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Free keywords: Contrast; Long-lived spin states; MRI; NMR relaxation
 Abstract: A method is proposed to create Long-Lived spin States (LLSs) from longitudinal spin magnetization, which is based on adiabatic switching of a Radio-Frequency (RF) field with proper frequency. The technique is simple to implement with standard Nuclear Magnetic Resonance (NMR) equipment, providing an excellent conversion of population from the triplet T+ (or T-) state to the singlet state of a pair of spins and back. The method has been tested for the amino acid tyrosine and its partially deuterated isotopomer; for the deuterated compound, we have achieved a LLS lifetime, which exceeds the longitudinal relaxation time by a factor of 21. Furthermore, by slightly modifying the method, an enhanced contrast with respect to LLSs in NMR spectra is achieved; contrast enhancements of more than 1200 are feasible. This enables efficient suppression of longitudinal spin magnetization in NMR allowing one to look selectively at LLSs. Using this method we have demonstrated that not only spectral but also spatial contrast can be achieved: we have obtained spatial NMR images with strongly improved contrast originating from the difference of LLS lifetimes at different positions in the sample.

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Language(s): eng - English
 Dates: 2015-10-102015-07-282015-10-312015-12-01
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Journal of Magnetic Resonance
Source Genre: Journal
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Publ. Info: San Diego [etc.] : Academic Press
Pages: - Volume / Issue: 261 Sequence Number: - Start / End Page: 64 - 72 Identifier: ISSN: 0022-2364
CoNE: /journals/resource/954922651175_1