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  Fronto-striatal organization: Defining functional and microstructural substrates of behavioural flexibility

Morris, L. S., Kundu, P., Dowell, N., Mechelmans, D. J., Favre, P., Irvine, M. A., et al. (2016). Fronto-striatal organization: Defining functional and microstructural substrates of behavioural flexibility. Cortex, 74, 118-133. doi:10.1016/j.cortex.2015.11.004.

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 Creators:
Morris, Laurel S.1, 2, Author
Kundu, Prantik3, 4, Author
Dowell, Nicholas5, Author
Mechelmans, Daisy J.3, Author
Favre, Pauline6, Author              
Irvine, Michael A.3, Author
Robbins, Trevor W.1, 2, Author
Daw, Nathaniel7, Author
Bullmore, Edward T.2, 3, 8, 9, Author
Harrison, Neil A.5, Author
Voon, Valerie2, 3, 8, 9, Author
Affiliations:
1Department of Psychology, University of Cambridge, United Kingdom, ou_persistent22              
2Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom, ou_persistent22              
3Department of Psychiatry, University of Cambridge, United Kingdom, ou_persistent22              
4Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, USA, ou_persistent22              
5Department of Psychiatry, Brighton and Sussex Medical School, United Kingdom, ou_persistent22              
6Laboratory of Psychology and Neurocognition, Université Grenoble Alpes, France, ou_persistent22              
7Center for Neural Science, New York University, NY, USA, ou_persistent22              
8Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom, ou_persistent22              
9NIHR Cambridge Biomedical Research Centre, United Kingdom, ou_persistent22              

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Free keywords: Fronto-striatal loops; Goal-directed; Habit; Microstructure; Neurite density
 Abstract: Discrete yet overlapping frontal-striatal circuits mediate broadly dissociable cognitive and behavioural processes. Using a recently developed multi-echo resting-state functional MRI sequence with greatly enhanced signal compared to noise ratios, we map frontal cortical functional projections to the striatum and striatal projections through the direct and indirect basal ganglia circuit. We demonstrate distinct limbic (ventromedial prefrontal regions, ventral striatum – VS, ventral tegmental area – VTA), motor (supplementary motor areas – SMAs, putamen, substantia nigra) and cognitive (lateral prefrontal and caudate) functional connectivity. We confirm the functional nature of the cortico-striatal connections, demonstrating correlates of well-established goal-directed behaviour (involving medial orbitofrontal cortex – mOFC and VS), probabilistic reversal learning (lateral orbitofrontal cortex – lOFC and VS) and attentional shifting (dorsolateral prefrontal cortex – dlPFC and VS) while assessing habitual model-free (SMA and putamen) behaviours on an exploratory basis. We further use neurite orientation and dispersion density imaging (NODDI) to show that more goal-directed model-based learning (MBc) is also associated with higher mOFC neurite density and habitual model-free learning (MFc) implicates neurite complexity in the putamen. This data highlights similarities between a computational account of MFc and conventional measures of habit learning. We highlight the intrinsic functional and structural architecture of parallel systems of behavioural control.

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Language(s): eng - English
 Dates: 2015-08-172015-05-012015-11-052015-11-182016-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cortex.2015.11.004
PMID: 26673945
PMC: PMC4729321
Other: Epub 2015
 Degree: -

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Title: Cortex
  Other : Cortex
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 74 Sequence Number: - Start / End Page: 118 - 133 Identifier: ISSN: 0010-9452
CoNE: https://pure.mpg.de/cone/journals/resource/954925393344