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  Selective sweeps versus introgression - population genetic dynamics of the murine leukemia virus receptor Xpr1 in wild populations of the house mouse (Mus musculus)

Hasenkamp, N., Solomon, T., & Tautz, D. (2015). Selective sweeps versus introgression - population genetic dynamics of the murine leukemia virus receptor Xpr1 in wild populations of the house mouse (Mus musculus). BMC Evolutionary Biology, 15(248). doi:10.1186/s12862-015-0528-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-20C3-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-20C4-3
Genre: Journal Article

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 Creators:
Hasenkamp, Natascha1, Author              
Solomon, Terry, Author
Tautz, Diethard1, Author              
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: MLV; Retrovirus; Receptor; House mouse; Population; Introgression
 Abstract: Background: The interaction between viruses and their receptors in the host can be expected to lead to an evolutionary arms race resulting in cycles of rapid adaptations. We focus here on the receptor gene Xpr1 (xenotropic and polytropic retrovirus receptor 1) for murine leukemia viruses (MLVs). In a previous screen for selective sweeps in mouse populations we discovered that a population from Germany was almost monomorphic for Xpr1 haplotypes, while a population from France was polymorphic. Results: Here we analyze Xpr1 sequences and haplotypes from a broad sample of wild mouse populations of two subspecies, M. m. domesticus and M. m. musculus, to trace the origins of this distinctive polymorphism pattern. We show that the high polymorphism in the population in France is caused by a relatively recent invasion of a haplotype from a population in Iran, rather than a selective sweep in Germany. The invading haplotype codes for a novel receptor variant, which has itself undergone a recent selective sweep in the Iranian population. Conclusions: Our data support a scenario in which Xpr1 is frequently subject to positive selection, possibly as a response to resistance development against recurrently emerging infectious viruses. During such an infection cycle, receptor variants that may convey viral resistance can be captured from another population and quickly introgress into populations actively dealing with the infectious virus. © 2015 Hasenkamp et al.

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Language(s): eng - English
 Dates: 2015-09-082015-10-302015-11-10
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1186/s12862-015-0528-5
BibTex Citekey: Hasenkamp2015
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Title: BMC Evolutionary Biology
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: 13 S. Volume / Issue: 15 (248) Sequence Number: - Start / End Page: - Identifier: ISSN: 1471-2148
CoNE: /journals/resource/111000136905006