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  Integration of intention and outcome for moral judgment in frontotemporal dementia: Brain structural signatures

Baez, S., Kanske, P., Matallana, D., Montanes, P., Reyes, P., Slachevsky, A., et al. (2016). Integration of intention and outcome for moral judgment in frontotemporal dementia: Brain structural signatures. Neurodegenerative Diseases, 16(3-4), 206-217. doi:10.1159/000441918.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-1E39-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1BE9-9
Genre: Journal Article

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 Creators:
Baez, S.1, 2, 3, Author
Kanske, Philipp4, Author              
Matallana, D.5, Author
Montanes, P.6, Author
Reyes, P.5, Author
Slachevsky, A.7, 8, 9, 10, Author
Matus, C.11, 12, Author
Vigliecca, N. S.2, 13, Author
Torralva, T.1, 3, Author
Manes, F.2, 3, 14, Author
Ibanez, A.1, 2, 3, 14, 15, 16, Author
Affiliations:
1Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina, ou_persistent22              
2National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina, ou_persistent22              
3UDP-INECO Foundation Core on Neuroscience, Diego Portales University, Santiago, Chile, ou_persistent22              
4Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              
5Instituto de Envejecimiento, Faculty of Medicine, University Javeriana, Bogota, Colombia, ou_persistent22              
6National University of Colombia, Bogota, Colombia, ou_persistent22              
7Departamento de Fisiopatología, Departamento de Ciencias Neurológicas Oriente, Faculty of Medicine, University of Chile, Santiago, Chile, ou_persistent22              
8Unidad de Neurología Cognitiva y Demencias, Institute of Neurology, Hospital del Salvador, Santiago, Chile, ou_persistent22              
9Centro de Investigación Avanzada en Educación, University of Chile, Santiago, Chile, ou_persistent22              
10Institute of Neurology, Clinica Alemana de Santiago, Chile, ou_persistent22              
11Hospital de Carabineros, Santiago, Chile, ou_persistent22              
12Clínica Fundación Médica San Cristóbal, Santiago, Chile, ou_persistent22              
13Instituto de Humanidades (IDH), Faculty of Philosophy and Humanities, National University of Córdoba, Argentina, ou_persistent22              
14ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, Australia, ou_persistent22              
15Universidad Autónoma del Caribe, Barranquilla, Colombia, ou_persistent22              
16School of Psychology, University Adolfo Ibañez, Santiago, Chile, ou_persistent22              

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Free keywords: Structural correlates; Magnetic resonance imaging; Voxel-based morphometry; Moral judgment; Behavioral variant of frontotemporal dementia
 Abstract: Background: Moral judgment has been proposed to rely on a distributed brain network. This function is impaired in behavioral variant frontotemporal dementia (bvFTD), a condition involving damage to some regions of this network. However, no studies have investigated moral judgment in bvFTD via structural neuroimaging. Methods: We compared the performance of 21 bvFTD patients and 19 controls on a moral judgment task involving scenarios that discriminate between the contributions of intentions and outcomes. Voxel-based morphometry was used to assess (a) the atrophy pattern in bvFTD patients, (b) associations between gray matter (GM) volume and moral judgments, and (c) structural differences between bvFTD subgroups (patients with relatively preserved moral judgment and patients with severer moral judgment impairments). Results: Patients judged attempted harm as more permissible and accidental harm as less permissible than controls. The groups' performance on accidental harm was associated with GM volume in the precuneus. In controls, it was al- so associated with the ventromedial prefrontal cortex (VMPFC). Also, both groups' performance on attempted harm was associated with GM volume in the temporoparietal junction. Patients exhibiting worse performance displayed smaller GM volumes in the precuneus and temporal pole. Conclusions: Results suggest that moral judgment abnormalities in bvFTD are associated with impaired integration of intentions and outcomes, which depends on an extended brain network. In bvFTD, moral judgment seems to critically depend on areas beyond the VMPFC.

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Language(s): eng - English
 Dates: 2015-06-042015-10-222016-02-092016-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1159/000441918
PMID: 26859768
Other: Epub 2016
 Degree: -

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Title: Neurodegenerative Diseases
  Other : Neurodegener. Dis.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 16 (3-4) Sequence Number: - Start / End Page: 206 - 217 Identifier: ISSN: 1660-2854
CoNE: https://pure.mpg.de/cone/journals/resource/111088195292342