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  Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.

Muhammad, K., Reddy-Alla, S., Driller, J. H., Schreiner, D., Rey, U., Böhme, M. A., et al. (2015). Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Nature Communications, 6: 8362. doi:10.1038/ncomms9362.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-1EE8-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-1CC3-4
Genre: Journal Article

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 Creators:
Muhammad, K., Author
Reddy-Alla, S., Author
Driller, J. H., Author
Schreiner, D., Author
Rey, U., Author
Böhme, M. A., Author
Hollmann, C., Author
Ramesh, N., Author
Depner, H., Author
Lützkendorf, J., Author
Matkovic, T., Author
Götz, T., Author
Bergeron, D. D., Author
Schmoranzer, J., Author
Göttfert, F.1, Author              
Holt, M., Author
Wahl, M. C., Author
Hell, S. W.1, Author              
Scheiffele, P., Author
Walter, A. M., Author
Loll, B., AuthorSigrist, S. J., Author more..
Affiliations:
1Department of NanoBiophotonics, MPI for Biophysical Chemistry, Max Planck Society, ou_578627              

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 Abstract: Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is needed to limit neurexin/neuroligin signalling by acting antagonistic to Syd-1. Loss of presynaptic spinophilin results in the formation of excess, but atypically small active zones. Neuroligin-1/neurexin-1/Syd-1 levels are increased at spinophilin mutant NMJs, and removal of single copies of the neurexin-1, Syd-1 or neuroligin-1 genes suppresses the spinophilin-active zone phenotype. Evoked transmission is strongly reduced at spinophilin terminals, owing to a severely reduced release probability at individual active zones. We conclude that presynaptic spinophilin fine-tunes neurexin/neuroligin signalling to control active zone number and functionality, thereby optimizing them for action potential-induced exocytosis.

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Language(s): eng - English
 Dates: 2015-10-16
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/ncomms9362
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Title: Nature Communications
Source Genre: Journal
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Pages: 15 Volume / Issue: 6 Sequence Number: 8362 Start / End Page: - Identifier: -