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  Bioorthogonal Enzymatic Activation of Caged Compounds

Ritter, C., Nett, N., Acevedo-Rocha, C. G., Lonsdale, R., Kraling, K., Dempwolff, F., et al. (2015). Bioorthogonal Enzymatic Activation of Caged Compounds. Angewandte Chemie International Edition, 54(45), 13440-13443. doi:10.1002/anie.201506739.

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 Creators:
Ritter, Cornelia1, Author
Nett, Natalie1, Author
Acevedo-Rocha, Carlos G.1, 2, 3, 4, Author              
Lonsdale, Richard1, 2, Author              
Kraling, Katja1, Author
Dempwolff, Felix3, Author
Hoebenreich, Sabrina1, Author
Graumann, Peter L.1, 3, Author
Reetz, Manfred T.1, 2, Author              
Meggers, Eric1, 5, Author
Affiliations:
1Philipps-Universität Marburg, Fachbereich Chemie, ou_persistent22              
2Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              
3LOEWE Zentrum Synthet Mikrobiol SYNMIKRO, D-35043 Marburg, Germany, ou_persistent22              
4Max Planck Inst Terr Mikrobiol, D-35043 Marburg, Germany, ou_persistent22              
5Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China, ou_persistent22              

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 Abstract: Engineered cytochrome P450 monooxygenase variants are reported as highly active and selective catalysts for the bioorthogonal uncaging of propargylic and benzylic ether protected substrates, including uncaging in living E. coli. observed selectivity is supported by induced-fit docking and molecular dynamics simulations. This proof-of-principle study points towards the utility of bioorthogonal enzyme/protecting group pairs for applications in the life sciences.

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Language(s): eng - English
 Dates: 2015-09-102015-11-02
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201506739
 Degree: -

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Title: Angewandte Chemie International Edition
  Other : Angew. Chem., Int. Ed.
  Other : Angew. Chem. Int. Ed.
  Other : Angewandte Chemie, International Edition
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 54 (45) Sequence Number: - Start / End Page: 13440 - 13443 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851