Bioorthogonal Enzymatic Activation of Caged Compounds

Ritter, Cornelia; Nett, Natalie; Acevedo-Rocha, Carlos G.; Lonsdale, Richard; Kraling, Katja; Dempwolff, Felix; Hoebenreich, Sabrina; Graumann, Peter L.; Reetz, Manfred T.; Meggers, Eric

doi:10.1002/anie.201506739

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Bioorthogonal Enzymatic Activation of Caged Compounds

Ritter, C., Nett, N., Acevedo-Rocha, C. G., Lonsdale, R., Kraling, K., Dempwolff, F., et al. (2015). Bioorthogonal Enzymatic Activation of Caged Compounds. Angewandte Chemie International Edition, 54(45), 13440-13443. doi:10.1002/anie.201506739.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-228F-2 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-1B55-2

Genre: Journal Article

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Creators:
Ritter, Cornelia¹, Author
Nett, Natalie¹, Author
Acevedo-Rocha, Carlos G.^{1, 2, 3, 4}, Author
Lonsdale, Richard^{1, 2}, Author
Kraling, Katja¹, Author
Dempwolff, Felix³, Author
Hoebenreich, Sabrina¹, Author
Graumann, Peter L.^{1, 3}, Author
Reetz, Manfred T.^{1, 2}, Author
Meggers, Eric^{1, 5}, Author

Affiliations:
1Philipps-Universität Marburg, Fachbereich Chemie, ou_persistent22
2Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588
3LOEWE Zentrum Synthet Mikrobiol SYNMIKRO, D-35043 Marburg, Germany, ou_persistent22
4Max Planck Inst Terr Mikrobiol, D-35043 Marburg, Germany, ou_persistent22
5Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China, ou_persistent22

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Abstract: Engineered cytochrome P450 monooxygenase variants are reported as highly active and selective catalysts for the bioorthogonal uncaging of propargylic and benzylic ether protected substrates, including uncaging in living E. coli. observed selectivity is supported by induced-fit docking and molecular dynamics simulations. This proof-of-principle study points towards the utility of bioorthogonal enzyme/protecting group pairs for applications in the life sciences.

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Language(s): eng - English

Dates: Published Online: 2015-09-10Date issued: 2015-11-02

Publication Status: Issued

Pages: 4

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Rev. Type: Peer

Identifiers: DOI: 10.1002/anie.201506739

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Title: Angewandte Chemie International Edition

Other : Angew. Chem., Int. Ed.

Other : Angew. Chem. Int. Ed.

Other : Angewandte Chemie, International Edition

Source Genre: Journal

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Publ. Info: Weinheim : Wiley-VCH

Pages: - Volume / Issue: 54 (45) Sequence Number: - Start / End Page: 13440 - 13443 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851