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  Sensorimotor decision making in the zebrafish tectum

Barker, A. J., & Baier, H. (2015). Sensorimotor decision making in the zebrafish tectum. Current Biology, 25(21), 2804-2814. doi:10.1016/j.cub.2015.09.055.

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 Creators:
Barker, Alison J.1, Author              
Baier, Herwig1, Author              
Affiliations:
1Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society, ou_1128545              

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Free keywords: VISUAL RESPONSE PROPERTIES; LARVAL ZEBRAFISH; OPTIC TECTUM; SUPERIOR COLLICULUS; TARGET SELECTION; EYE-MOVEMENTS; PREY CAPTURE; NEURONAL-ACTIVITY; CELLS; INACTIVATION
 Abstract: An animal's survival depends on its ability to correctly evaluate sensory stimuli and select appropriate behavioral responses. When confronted with ambiguous stimuli, the brain is faced with the task of selecting one action while suppressing others. Although conceptually simple, the site and substrate of this elementary form of decision making is still largely unknown. Zebrafish larvae respond to a moving dot stimulus in either of two ways: a small object (potential prey) evokes approach, whereas a large object (potential predator) is avoided. The classification of object size relies on processing in the optic tectum. We genetically identified a population of cells, largely comprised of glutamatergic tectal inter-neurons with non-stratified morphologies, that are specifically required for approach toward small objects. When these neurons are ablated, we found that the behavioral response is shifted; small objects now tend to elicit avoidance. Conversely, optogenetic facilitation of neuronal responses with channelrhodopsin (ChR2) enhances approaches to small objects. Calcium imaging in head-fixed larvae shows that a large proportion of these neurons are tuned to small sizes. Their receptive fields are shaped by input from retinal ganglion cells (RGCs) that are selective for prey identity. We propose a model in which valence-based decisions arise, at a fundamental level, from competition between dedicated sensorimotor pathways in the tectum.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000364262500022
DOI: 10.1016/j.cub.2015.09.055
 Degree: -

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Title: Current Biology
  Abbreviation : Curr. Biol.
Source Genre: Journal
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Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 25 (21) Sequence Number: - Start / End Page: 2804 - 2814 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107