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  Visualization of Multimerization and Self-Assembly of DNA-Functionalized Gold Nanoparticles Using In-Liquid Transmission Electron Microscopy

Keskin, S., Besztejan, S., Kassier, G., Manz, S., Bücker, R., Riekeberg, S., et al. (2015). Visualization of Multimerization and Self-Assembly of DNA-Functionalized Gold Nanoparticles Using In-Liquid Transmission Electron Microscopy. The Journal of Physical Chemistry Letters, 6(22), 4487-4492. doi:10.1021/acs.jpclett.5b02075.

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Keskin, Sercan1, Autor           
Besztejan, Stephanie2, 3, Autor           
Kassier, Günther1, Autor           
Manz, Stephanie1, Autor           
Bücker, Robert1, Autor           
Riekeberg, Svenja4, Autor
Trieu, Hoc Khiem4, Autor
Rentmeister, Andrea5, 6, Autor
Miller, R. J. Dwayne1, 3, 7, Autor           
Affiliations:
1Miller Group, Atomically Resolved Dynamics Department, Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_1938288              
2University of Hamburg, Chemistry Department, Institute for Biochemistry and Molecular Biology, Martin-Luther-King Platz 6, 20146 Hamburg, Germany, ou_persistent22              
3The Hamburg Centre for Ultrafast Imaging, Luruper Chaussee 149, 22761 Hamburg, Germany, ou_persistent22              
4Hamburg University of Technology (TUHH), Institute of Microsystems Technology, Eißendorfer Straße 42, 21073 Hamburg, Germany, ou_persistent22              
5Westfälische Wilhelms-Universität Münster, Institute of Biochemistry, 48149 Muenster, Germany, ou_persistent22              
6Cells-in-Motion Cluster of Excellence (EXC 1003 − CiM), University of Muenster, 48149 Muenster, Germany, ou_persistent22              
7Departments of Chemistry and Physics, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada, ou_persistent22              

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 Zusammenfassung: Base-pairing stability in DNA-gold nanoparticle (DNA-AuNP) multimers along with their dynamics under different electron beam intensities was investigated with in-liquid transmission electron microscopy (in-liquid TEM). Multimer formation was triggered by hybridization of DNA oligonucleotides to another DNA strand (Hyb-DNA) related to the concept of DNA origami. We analyzed the degree of multimer formation for a number of samples and a series of control samples to determine the specificity of the multimerization during the TEM imaging. DNA-AuNPs with Hyb-DNA showed an interactive motion and assembly into 1D structures once the electron beam intensity exceeds a threshold value. This behavior was in contrast with control studies with noncomplementary DNA linkers where statistically significantly reduced multimerization was observed and for suspensions of citrate-stabilized AuNPs without DNA, where we did not observe any significant motion or aggregation. These findings indicate that DNA base-pairing interactions are the driving force for multimerization and suggest a high stability of the DNA base pairing even under electron exposure.

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Sprache(n): eng - English
 Datum: 2015-09-182015-10-282015-10-282015-11-19
 Publikationsstatus: Erschienen
 Seiten: 6
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1021/acs.jpclett.5b02075
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Titel: The Journal of Physical Chemistry Letters
  Andere : J. Phys. Chem. Lett.
  Kurztitel : JPCLett
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Washington, DC : American Chemical Society
Seiten: - Band / Heft: 6 (22) Artikelnummer: - Start- / Endseite: 4487 - 4492 Identifikator: CoNE: https://pure.mpg.de/cone/journals/resource/1948-7185