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  Transactivation of the human c-myc gene by c-Myb.

Zobel, A., Kalkbrenner, F., Vorbrüggen, G., & Mölling, K. (1992). Transactivation of the human c-myc gene by c-Myb. Biochemical and Biophysical Research Communications, 186(2), 715-722.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-294C-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-294D-B
Genre: Journal Article

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2235567.pdf (Publisher version), 601KB
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Zobel, A., Author
Kalkbrenner, F., Author
Vorbrüggen, G.1, Author              
Mölling, K., Author
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1Research Group of Molecular Cell Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578593              

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 Abstract: We analyse the contribution of six Myb-binding sites in the upstream c-myc sequences to transactivation by co-transfection assays. Surprisingly, deletion of the six Myb-binding sites did not influence the transactivation of c-myc by c-Myb protein. Instead, the strongest transactivation was observed with a c-myc reporter plasmid which contains only 450 bp of exon 1 including the c-myc promoter P2. An exchange of the DNA binding domain of c-Myb by that of GAL4 led only to small transactivation effects indicating that the DNA binding domain of c-Myb is essential for transactivation of the c-myc gene. These results suggest either an indirect transactivation mechanism of the c-myc gene by c-Myb proteins or a role of the DNA binding domain for additional effects than DNA binding.

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Language(s): eng - English
 Dates: 1992-07-31
 Publication Status: Published in print
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Title: Biochemical and Biophysical Research Communications
Source Genre: Journal
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Pages: - Volume / Issue: 186 (2) Sequence Number: - Start / End Page: 715 - 722 Identifier: -