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Free keywords:
C-H ACTIVATION; N-TYPE REACTIONS; ALKENE HYDROGENATION; COBALT
CATALYSIS; RING-EXPANSION; HOMOALLYL ALCOHOLS; ORGANIC-SYNTHESIS;
CARBOXYLIC-ACIDS; 7-MEMBERED RINGS; MILD CONDITIONSChemistry; cobalt; C-C bond activation; base metal; beta-carbon elimination;
alcohols;
Abstract:
We demonstrate that a simple Co(III)-complex can efficiently catalyze the cleavage of unstrained C-C bonds via the beta-carbon elimination of secondary and tertiary alcohols bearing a directing group. The cobalt-aryl intermediate generated under the reaction conditions can be trapped by different electrophiles to generate a new carbon carbon bond. Some essential features of this new Co-based mechanistic manifold were revealed by preliminary mechanistic studies.
