ausblenden:
Schlagwörter:
D1 receptor antagonists, deliberate self-harm, drug treatment for nonsuicidal self-injury, neuroleptics, nonsuicidal self-injury treatment
Zusammenfassung:
INTRODUCTION: There is no drug treatment for nonsuicidal self-injury
(NSSI), a highly prevalent and burdensome symptom of several psychiatric
diseases like posttraumatic stress disorder (PTSD), personality
disorders, and major depression (MD).
METHODS: Here, we present a retrospective series of three patients
demonstrating a persistent remission in MD-associated NSSI in response
to treatment with antipsychotics possessing marked D1 receptor
antagonistic activity.
RESULTS: To the best of the authors' knowledge, the case series
presented is only the second clinical paper suggesting a role for D1
antagonists in NSSI drug therapy.
CONCLUSIONS: Together with previously published data from rodent models,
the findings suggest a role for D1 antagonists in NSSI drug therapy and
hence for the D1 receptor in NSSI pathogenesis. This conclusion is
limited by the facts that the patients presented here received
polypharmacy and that the D1 receptor antagonistic antipsychotics
suggested here as effective 'anti-auto-aggressants' do not address D1
receptors only but multiple neurotransmitter receptors/systems.
