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  Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications

Fernandes, B. S., Steiner, J., Berk, M., Molendijk, M. L., Gonzalez-Pinto, A., Turck, C. W., Nardin, P., & Goncalves, C.-A. (2015). Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications. MOLECULAR PSYCHIATRY, 20(9), 1108-1119. doi:10.1038/mp.2014.117.

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資料種別: 学術論文

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 作成者:
Fernandes, B. S.1, 著者
Steiner, J.1, 著者
Berk, M.1, 著者
Molendijk, M. L.1, 著者
Gonzalez-Pinto, A.1, 著者
Turck, C. W.2, 著者           
Nardin, P.1, 著者
Goncalves, C-A1, 著者
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1external, ou_persistent22              
2Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

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 要旨: It has been postulated that schizophrenia (SZ) is related to a lower expression of brain-derived neurotrophic factor (BDNF). In the past few years, an increasing number of divergent clinical studies assessing BDNF in serum and plasma have been published. It is now possible to verify the relationship between BDNF levels and severity of symptoms in SZ as well as the effects of antipsychotic drugs on BDNF using meta-analysis. The aims of this study were to verify if peripheral BDNF is decreased in SZ, whether its levels are correlated with positive and negative symptomatology and if BDNF levels change after antipsychotic treatment. This report consists of two distinct meta-analyses of peripheral BDNF in SZ including a total of 41 studies and more than 7000 participants: (1) peripheral BDNF levels in serum and plasma were moderately reduced in SZ compared with controls. Notably, this decrease was accentuated with the disease duration. However, the extent of peripheral BDNF level decrease did not correlate with the severity of positive and negative symptoms. (2) In plasma, but not serum, peripheral BDNF levels are consistently increased after antipsychotic treatment irrespective of the patient's response to medication. In conclusion, there is compelling evidence that there are decreased levels of peripheral BDNF in SZ, in parallel to previously described reduced cerebral BDNF expression. It remains unclear whether these systemic changes are causally related to the development of SZ or if they are merely a pathologic epiphenomenon.

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言語: eng - English
 日付: 2015-09
 出版の状態: 出版
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 識別子(DOI, ISBNなど): ISI: 000360175500012
DOI: 10.1038/mp.2014.117
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出版物名: MOLECULAR PSYCHIATRY
種別: 学術雑誌
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出版社, 出版地: London, UK : Macmillan Publishers Limited Nature Publishing Group
ページ: - 巻号: 20 (9) 通巻号: - 開始・終了ページ: 1108 - 1119 識別子(ISBN, ISSN, DOIなど): ISSN: 1359-4184