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  Relationship of monoamine oxidase: A distribution volume to postpartum depression and postpartum crying

Sacher, J., Rekkas, V. P., Wilson, A. A., Houle, S., Romano, L., Hamidi, J., et al. (2015). Relationship of monoamine oxidase: A distribution volume to postpartum depression and postpartum crying. Neuropsychopharmacology, 40(2), 429-435. doi:10.1038/npp.2014.190.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-3260-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7A74-2
Genre: Journal Article

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 Creators:
Sacher, Julia1, 2, 3, 4, Author              
Rekkas, Vivien P.1, 2, Author
Wilson, Alan A.1, Author
Houle, Sylvain1, Author
Romano, Leslie1, 2, Author
Hamidi, Jinous2, Author
Rusjan, Pablo1, Author
Fan, Ian1, 2, Author
Stewart, Donna E.5, Author
Meyer, Jeffrey H.1, 2, Author
Affiliations:
1CAMH Research Imaging Centre, Campbell Family Mental Health Research Institute, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
2Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5Women's Health Program, University Health Network, University of Toronto, ON, Canada, ou_persistent22              

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 Abstract: Postpartum depression (PPD) has a prevalence rate of 13% and a similarly high proportion of women report a subclinical state of one or more major depressive episode symptoms. The aim was to investigate whether monoamine oxidase-A (MAO-A) VT, an index of MAO-A density, is increased in the prefrontal and anterior cingulate cortex (PFC and ACC), during PPD or when a PPD spectrum symptom, greater predisposition to crying, is present. MAO-A is an enzyme that increases in density after estrogen decline, and has several functions including creating oxidative stress, influencing apoptosis and monoamine metabolism. Fifty-seven women were recruited including 15 first-onset, antidepressant naive, PPD subjects, 12 postpartum healthy who cry due to sad mood, 15 asymptomatic postpartum healthy women, and 15 healthy women not recently pregnant. Each underwent [11C]-harmine positron emission tomography scanning to measure MAO-A VT. Both PPD and greater predisposition to crying were associated with greater MAO-A VT in the PFC and ACC (multivariate analysis of variance (MANOVA), group effect, F21,135=1.856; p=0.019; mean combined region elevation 21% and 14% in PPD and crying groups, respectively, relative to postpartum asymptomatic). Greater MAO-A VT in the PFC and ACC represents a new biomarker in PPD, and the PPD symptom of predisposition to crying. Novel strategies for preventing PPD (and some PPD symptoms) may be possible by avoiding environmental conditions that elevate MAO-A level and enhancing conditions that normalize MAO-A level. These findings also argue for clinical trials in PPD with the newer, well-tolerated MAO-A inhibitor antidepressants.

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Language(s): eng - English
 Dates: 2014-02-252014-07-072014-08-272015-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/npp.2014.190
PMID: 25074638
PMC: PMC4443957
Other: Epub 2014
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Title: Neuropsychopharmacology
Source Genre: Journal
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Pages: - Volume / Issue: 40 (2) Sequence Number: - Start / End Page: 429 - 435 Identifier: ISSN: 0893-133X
CoNE: /journals/resource/954925558485