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  Reward signal in a recurrent circuit drives appetitive long-term memory formation

Ichinose, T., Aso, Y., Yamagata, N., Abe, A., Rubin, G. M., & Tanimoto, H. (2015). Reward signal in a recurrent circuit drives appetitive long-term memory formation. ELIFE, 4: e10719. doi:10.7554/eLife.10719.

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 Creators:
Ichinose, Toshiharu1, Author              
Aso, Yoshinori2, Author
Yamagata, Nobuhiro1, Author              
Abe, Ayako2, Author
Rubin, Gerald M.2, Author
Tanimoto, Hiromu1, Author              
Affiliations:
1Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society, ou_1113555              
2external, ou_persistent22              

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Free keywords: DROSOPHILA MUSHROOM BODY; GLUTAMIC-ACID DECARBOXYLASE; DOPAMINE NEURONS; OLFACTORY MEMORIES; FEEDBACK NEURONS; EFFERENT NEURONS; APIS-MELLIFERA; ODOR MEMORY; 2 PAIRS; EXPRESSION
 Abstract: Dopamine signals reward in animal brains. A single presentation of a sugar reward to Drosophila activates distinct subsets of dopamine neurons that independently induce short- and long-term olfactory memories (STM and LTM, respectively). In this study, we show that a recurrent reward circuit underlies the formation and consolidation of LTM. This feedback circuit is composed of a single class of reward-signaling dopamine neurons (PAM-alpha 1) projecting to a restricted region of the mushroom body (MB), and a specific MB output cell type, MBON-alpha 1, whose dendrites arborize that same MB compartment. Both MBON-alpha 1 and PAM-alpha 1 neurons are required during the acquisition and consolidation of appetitive LTM. MBON-alpha 1 additionally mediates the retrieval of LTM, which is dependent on the dopamine receptor signaling in the MB alpha/beta neurons. Our results suggest that a reward signal transforms a nascent memory trace into a stable LTM using a feedback circuit at the cost of memory specificity.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published online
 Pages: 18
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000364819300001
DOI: 10.7554/eLife.10719
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Title: ELIFE
Source Genre: Journal
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Publ. Info: SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND : ELIFE SCIENCES PUBLICATIONS LTD
Pages: - Volume / Issue: 4 Sequence Number: e10719 Start / End Page: - Identifier: ISSN: 2050-084X