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  The perception of touch and the ventral somatosensory pathway

Preusser, S., Thiel, S. D., Rook, C., Roggenhofer, E., Kosatschek, A., Draganski, B., et al. (2015). The perception of touch and the ventral somatosensory pathway. Brain, 138(3), 540-548. doi:10.1093/brain/awu370.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-3385-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7920-1
Genre: Journal Article

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 Creators:
Preusser, Sven1, Author              
Thiel, Sabrina D.1, 2, Author              
Rook, Carolin3, Author
Roggenhofer, Elisabeth1, 3, 4, Author              
Kosatschek, Anna5, Author              
Draganski, Bogdan4, Author              
Blankenburg, Felix6, 7, Author
Driver, Jon8, Author
Villringer, Arno1, 3, 6, 9, Author              
Pleger, Burkhard1, 3, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
7Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
8Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
9Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Perception; Touch; Somatosensory cortex; Lesion symptom mapping; Ventral somatosensory pathway
 Abstract: In humans, touching the skin is known to activate, among others, the contralateral primary somatosensory cortex on the postcentral gyrus together with the bilateral parietal operculum (i.e. the anatomical site of the secondary somatosensory cortex). But which brain regions beyond the postcentral gyrus specifically contribute to the perception of touch remains speculative. In this study we collected structural magnetic resonance imaging scans and neurological examination reports of patients with brain injuries or stroke in the left or right hemisphere, but not in the postcentral gyrus as the entry site of cortical somatosensory processing. Using voxel-based lesion-symptom mapping, we compared patients with impaired touch perception (i.e. hypoaesthesia) to patients without such touch impairments. Patients with hypoaesthesia as compared to control patients differed in one single brain cluster comprising the contralateral parietal operculum together with the anterior and posterior insular cortex, the putamen, as well as subcortical white matter connections reaching ventrally towards prefrontal structures. This finding confirms previous speculations on the ‘ventral pathway of somatosensory perception’ and causally links these brain structures to the perception of touch.

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Language(s): eng - English
 Dates: 2014-07-082014-10-292014-12-242015-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/brain/awu370
PMID: 25541190
PMC: PMC4408426
Other: Epub 2014
 Degree: -

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Title: Brain
  Other : Brain
Source Genre: Journal
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Pages: - Volume / Issue: 138 (3) Sequence Number: - Start / End Page: 540 - 548 Identifier: ISSN: 0006-8950
CoNE: https://pure.mpg.de/cone/journals/resource/954925385135