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  The perception of touch and the ventral somatosensory pathway

Preusser, S., Thiel, S. D., Rook, C., Roggenhofer, E., Kosatschek, A., Draganski, B., et al. (2015). The perception of touch and the ventral somatosensory pathway. Brain, 138(3), 540-548. doi:10.1093/brain/awu370.

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https://doi.org/10.1093/brain/awu370 (Publisher version)
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 Creators:
Preusser, Sven1, Author           
Thiel, Sabrina D.1, 2, Author           
Rook, Carolin3, Author
Roggenhofer, Elisabeth1, 3, 4, Author           
Kosatschek, Anna5, Author           
Draganski, Bogdan4, Author           
Blankenburg, Felix6, 7, Author
Driver, Jon8, Author
Villringer, Arno1, 3, 6, 9, Author           
Pleger, Burkhard1, 3, Author           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
7Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
8Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
9Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Perception; Touch; Somatosensory cortex; Lesion symptom mapping; Ventral somatosensory pathway
 Abstract: In humans, touching the skin is known to activate, among others, the contralateral primary somatosensory cortex on the postcentral gyrus together with the bilateral parietal operculum (i.e. the anatomical site of the secondary somatosensory cortex). But which brain regions beyond the postcentral gyrus specifically contribute to the perception of touch remains speculative. In this study we collected structural magnetic resonance imaging scans and neurological examination reports of patients with brain injuries or stroke in the left or right hemisphere, but not in the postcentral gyrus as the entry site of cortical somatosensory processing. Using voxel-based lesion-symptom mapping, we compared patients with impaired touch perception (i.e. hypoaesthesia) to patients without such touch impairments. Patients with hypoaesthesia as compared to control patients differed in one single brain cluster comprising the contralateral parietal operculum together with the anterior and posterior insular cortex, the putamen, as well as subcortical white matter connections reaching ventrally towards prefrontal structures. This finding confirms previous speculations on the ‘ventral pathway of somatosensory perception’ and causally links these brain structures to the perception of touch.

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Language(s): eng - English
 Dates: 2014-07-082014-10-292014-12-242015-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/brain/awu370
PMID: 25541190
PMC: PMC4408426
Other: Epub 2014
 Degree: -

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Project name : -
Grant ID : 01GQ0975, 18GL4DW4
Funding program : -
Funding organization : Federal Ministry of Education & Research (BMBF)

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Title: Brain
  Other : Brain
Source Genre: Journal
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Pages: - Volume / Issue: 138 (3) Sequence Number: - Start / End Page: 540 - 548 Identifier: ISSN: 0006-8950
CoNE: https://pure.mpg.de/cone/journals/resource/954925385135