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  The cortical signature of central poststroke pain: Gray matter decreases in somatosensory, insular, and prefrontal cortices

Krause, T., Asseyer, S., Taskin, B., Flöel, A., Witte, V., Mueller, K., et al. (2016). The cortical signature of central poststroke pain: Gray matter decreases in somatosensory, insular, and prefrontal cortices. Cerebral Cortex, 26(1), 80-88. doi:10.1093/cercor/bhu177.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-33B7-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1426-C
Genre: Journal Article

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 Creators:
Krause, T.1, 2, Author
Asseyer, S.1, Author
Taskin, Birol1, 3, Author              
Flöel, A.1, 2, 4, Author
Witte, Veronica1, 3, 4, Author              
Mueller, Karsten5, Author              
Fiebach, J. B.2, Author
Villringer, K.2, Author
Villringer, Arno4, Author              
Jungehulsing, G. J.1, 2, 6, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Klinik für Neurologie, Jüdisches Krankenhaus Berlin, Germany, ou_persistent22              

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Free keywords: Cortical plasticity; MRI; Pain; Stroke
 Abstract: It has been proposed that cortical structural plasticity plays a crucial role in the emergence and maintenance of chronic pain. Various dis- tinct pain syndromes have accordingly been linked to specific pat- terns of decreases in regional gray matter volume (GMV). However, it is not known whether central poststroke pain (CPSP) is also asso- ciated with cortical structural plasticity. To determine this, we em- ployed T1-weighted magnetic resonance imaging at 3 T and voxel- based morphometry in 45 patients suffering from chronic subcortical sensory stroke with (n = 23) and without CPSP (n = 22), and healthy matched controls (n = 31). CPSP patients showed decreases in GMV in comparison to healthy controls, involving secondary som- atosensory cortex (S2), anterior as well as posterior insular cortex, ventrolateral prefrontal and orbitofrontal cortex, temporal cortex, and nucleus accumbens. Comparing CPSP patients to nonpain pa- tients revealed a similar but more restricted pattern of atrophy com- prising S2, ventrolateral prefrontal and temporal cortex. Additionally, GMV in the ventromedial prefrontal cortex negatively correlated to pain intensity ratings. This shows for the first time that CPSP is ac- companied by a unique pattern of widespread structural plasticity, which involves the sensory-discriminative areas of insular/somato- sensory cortex, but also expands into prefrontal cortex and ventral striatum, where emotional aspects of pain are processed.

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Language(s): eng - English
 Dates: 2014-08-162016-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhu177
PMID: 25129889
Other: Epub 2014
 Degree: -

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 26 (1) Sequence Number: - Start / End Page: 80 - 88 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440