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  Transport selectivity of nuclear pores, phase separation, and membraneless organelles.

Schmidt, H. B., & Görlich, D. (2016). Transport selectivity of nuclear pores, phase separation, and membraneless organelles. Trends in Biochemical Sciences, 41(1), 46-61. doi:10.1016/j.tibs.2015.11.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-42AE-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-19C7-F
Genre: Journal Article

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2240132.pdf (Publisher version), 3MB
 
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 Creators:
Schmidt, H. B., Author
Görlich, D.1, Author              
Affiliations:
1Department of Cellular Logistics, MPI for biophysical chemistry, Max Planck Society, ou_578574              

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Free keywords: FG domains; Intracellular phase separation; Intrinsically disordered proteins; Nuclear pore; Protein disorder; Protein phases
 Abstract: Nuclear pore complexes (NPCs) provide a selective passageway for receptor-mediated active transport between nucleus and cytoplasm, while maintaining the distinct molecular compositions of both compartments at large. In this review we discuss how NPCs gain a remarkable sorting selectivity from non-globular FG domains and their phase separation into dense polymer meshworks. The resulting sieve-like FG hydrogels are effective barriers to normal macromolecules but are at the same time highly permeable to shuttling nuclear transport receptors, which bind to FG motifs as well as to their designated cargoes. Phase separation driven by disordered protein domains was recently also recognized as being pivotal to the formation of membraneless organelles, making it an important emerging principle in cell biology.

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Language(s): eng - English
 Dates: 2015-12-162016-01
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.tibs.2015.11.001
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Title: Trends in Biochemical Sciences
Source Genre: Journal
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Pages: - Volume / Issue: 41 (1) Sequence Number: - Start / End Page: 46 - 61 Identifier: -