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  Loss of BAF (mSWI/SNF) complexes causes global transcriptional and chromatin state changes in forebrain development.

Narayanan, R., Pirouz, M., Kerimoglu, C., Pham, L., Wagener, R. J., Kiszka, K. A., et al. (2015). Loss of BAF (mSWI/SNF) complexes causes global transcriptional and chromatin state changes in forebrain development. Cell Reports, 13(9), 1842-1854. doi:10.1016/j.celrep.2015.10.046.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-437B-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-2A73-7
Genre: Journal Article

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Narayanan, R., Author
Pirouz, M.1, Author              
Kerimoglu, C., Author
Pham, L., Author
Wagener, R. J., Author
Kiszka, K. A., Author
Rosenbusch, J., Author
Seong, R. H., Author
Kessel, M.1, Author              
Fischer, A., Author
Stoykova, A.2, Author              
Staiger, J. F., Author
Tuoc, T. C.2, Author              
Affiliations:
1Research Group of Developmental Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_578586              
2Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

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 Abstract: BAF (Brg/Brm-associated factors) complexes play important roles in development and are linked to chromatin plasticity at selected genomic loci. Nevertheless, a full understanding of their role in development and chromatin remodeling has been hindered by the absence of mutants completely lacking BAF complexes. Here, we report that the loss of BAF155/BAF170 in double-conditional knockout (dcKO) mice eliminates all known BAF subunits, resulting in an overall reduction in active chromatin marks (H3K9Ac), a global increase in repressive marks (H3K27me2/3), and downregulation of gene expression. We demonstrate that BAF complexes interact with H3K27 demethylases (JMJD3 and UTX) and potentiate their activity. Importantly, BAF complexes are indispensable for forebrain development, including proliferation, differentiation, and cell survival of neural progenitor cells. Our findings reveal a molecular mechanism mediated by BAF complexes that controls the global transcriptional program and chromatin state in development.

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Language(s): eng - English
 Dates: 2015-11-192015-12-01
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.celrep.2015.10.046
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Title: Cell Reports
Source Genre: Journal
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Pages: - Volume / Issue: 13 (9) Sequence Number: - Start / End Page: 1842 - 1854 Identifier: -