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  Brain tumour cells interconnect to a functional and resistant network

Osswald, M., Jung, E., Sahm, F., Solecki, G., Venkataramani, V., Blaes, J., et al. (2015). Brain tumour cells interconnect to a functional and resistant network. Nature, 528(7580), 93-98. doi:10.1038/nature16071.

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 Creators:
Osswald, Matthias, Author
Jung, Erik, Author
Sahm, Felix, Author
Solecki, Gergely, Author
Venkataramani, Varun, Author
Blaes, Jonas, Author
Weil, Sophie, Author
Horstmann, Heinz, Author
Wiestler, Benedikt, Author
Syed, Mustafa, Author
Huang, Lulu, Author
Ratliff, Miriam, Author
Jazi, Kianush Karimian, Author
Kurz, Felix T., Author
Schmenger, Torsten, Author
Lemke, Dieter, Author
Goemmel, Miriam, Author
Pauli, Martin, Author
Liao, Yunxiang, Author
Haering, Peter, Author
Pusch, Stefan, AuthorHerl, Verena, AuthorSteinhaeuser, Christian, AuthorKrunic, Damir, AuthorJarahian, Mostafa, AuthorMiletic, Hrvoje, AuthorBerghoff, Anna S., AuthorGriesbeck, Oliver1, Author           Kalamakis, Georgios, AuthorGaraschuk, Olga, AuthorPreusser, Matthias, AuthorWeiss, Samuel, AuthorLiu, Haikun, AuthorHeiland, Sabine, AuthorPlatten, Michael, AuthorHuber, Peter E., AuthorKuner, Thomas, Authorvon Deimling, Andreas, AuthorWick, Wolfgang, AuthorWinkler, Frank, Author more..
Affiliations:
1Research Group: Cellular Dynamics / Griesbeck, MPI of Neurobiology, Max Planck Society, ou_1113560              

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Free keywords: MEMBRANE NANOTUBES; CALCIUM WAVES; STEM-CELLS; SELF-RENEWAL; IN-VIVO; GROWTH; GLIOMA; ASTROCYTES; GAP-43; OLIGODENDROGLIOMA
 Abstract: Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized by diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend ultra-long membrane protrusions, and use these distinct tumour microtubes as routes for brain invasion, proliferation, and to interconnect over long distances. The resulting network allows multicellular communication through microtube-associated gap junctions. When damage to the network occurred, tumour microtubes were used for repair. Moreover, the microtube-connected astrocytoma cells, but not those remaining unconnected throughout tumour progression, were protected from cell death inflicted by radiotherapy. The neuronal growth-associated protein 43 was important for microtube formation and function, and drove microtube-dependent tumour cell invasion, proliferation, interconnection, and radioresistance. Oligodendroglial brain tumours were deficient in this mechanism. In summary, astrocytomas can develop functional multicellular network structures. Disconnection of astrocytoma cells by targeting their tumour microtubes emerges as a new principle to reduce the treatment resistance of this disease.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 19
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000365606000054
DOI: 10.1038/nature16071
 Degree: -

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 528 (7580) Sequence Number: - Start / End Page: 93 - 98 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238