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  Brain regulation of food craving: Relationships with weight status and eating behavior

Dietrich, A., Hollmann, M., Mathar, D., Villringer, A., & Horstmann, A. (2016). Brain regulation of food craving: Relationships with weight status and eating behavior. International Journal of Obesity, 40, 982-989. doi:10.1038/ijo.2016.28.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-5AD0-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19EB-9
Genre: Journal Article

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 Creators:
Dietrich, Anja1, Author              
Hollmann, Maurice1, Author              
Mathar, David1, 2, Author              
Villringer, Arno1, 2, 3, 4, 5, Author              
Horstmann, Annette1, 2, 5, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5University Hospital Leipzig, Germany, ou_persistent22              

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 Abstract: Objectives: Food craving is a driving force for overeating and obesity. However, the relationship between brain mechanisms involved in its regulation and weight status is still an open issue. Gaps in the studied body mass index (BMI) distributions and focusing on linear analyses might have contributed to this lack of knowledge. Here, we investigated brain mechanisms of craving regulation using functional magnetic resonance imaging in a balanced sample including normal-weight, overweight and obese participants. We investigated associations between characteristics of obesity, eating behavior and regulatory brain function focusing on nonlinear relationships. Subjects/Methods: Forty-three hungry female volunteers (BMI: 19.4–38.8 kg m−2, mean: 27.5±5.3 s.d.) were presented with visual food stimuli individually pre-rated according to tastiness and healthiness. The participants were instructed to either admit to the upcoming craving or regulate it. We analyzed the relationships between regulatory brain activity as well as functional connectivity and BMI or eating behavior (Three-Factor Eating Questionnaire, scales: Cognitive Restraint, Disinhibition). Results: During regulation, BMI correlated with brain activity in the left putamen, amygdala and insula in an inverted U-shaped manner. Functional connectivity between the putamen and the dorsolateral prefrontal cortex (dlPFC) correlated positively with BMI, whereas that of amygdala with pallidum and lingual gyrus was nonlinearly (U-shaped) associated with BMI. Disinhibition correlated negatively with the strength of functional connectivity between amygdala and dorsomedial prefrontal (dmPFC) cortex as well as caudate. Conclusions: This study is the first to reveal quadratic relationships of food-related brain processes and BMI. Reported nonlinear associations indicate inverse relationships between regulation-related motivational processing in the range of normal weight/overweight compared with the obese range. Connectivity analyses suggest that the need for top-down (dlPFC) adjustment of striatal value representations increases with BMI, whereas the interplay of self-monitoring (dmPFC) or eating-related strategic action planning (caudate) and salience processing (amygdala) might be hampered with high Disinhibition.

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Language(s): eng - English
 Dates: 2016-01-082015-08-172016-01-132016-04-262016-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/ijo.2016.28
PMID: 26883294
Other: Epub 2016
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Title: International Journal of Obesity
  Other : Int. J. Obes.
Source Genre: Journal
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Pages: - Volume / Issue: 40 Sequence Number: - Start / End Page: 982 - 989 Identifier: ISSN: 0307-0565
CoNE: https://pure.mpg.de/cone/journals/resource/954925515513_1