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  Miniaturization of fluorescence microscopes using fibre optics

Helmchen, F. (2002). Miniaturization of fluorescence microscopes using fibre optics. Experimental Physiology, 87(6), 737-745. doi:10.1113/EPH8702478.

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Genre: Journal Article
Alternative Title : Miniaturization of fluorescence microscopes using fibre optics

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ExpPhysiol_87_2002_737.pdf (Any fulltext), 728KB
 
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 Creators:
Helmchen, Fritjof1, Author           
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: In both medical research and diagnostics characterization of biological tissue on the cellular level relies on high-resolution optical microscopy. In most cases, however, tissue is excised for microscopic investigation, in part because conventional microscopes are bulky instruments. Imaging of cells in the intact living organism has been difficult. Over the last decade several groups have developed miniature confocal microscopes that use fibre optics to deliver light to the specimen and to measure either reflected or excited fluorescence light. In addition, two-photon excitation recently has been employed in a small portable ‘fibrescope’. A potential clinical application of these microscope probes is their endoscopic use for optical biopsy of inner organs or guidance of conventional biopsy. As a mobile research tool they may permit imaging of neuronal activity in the brain of awake, behaving animals. Here, we review technological approaches to build iniaturized fluorescence microscopes and discuss their potential applications.

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Language(s): eng - English
 Dates: 2002-09-092002-09-172004-05-042002-11-01
 Publication Status: Published in print
 Pages: 9
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 Table of Contents: -
 Rev. Type: Peer
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Title: Experimental Physiology
  Other : Exp. Physiol.
Source Genre: Journal
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Publ. Info: Cambridge : Cambridge University Press for the Physiological Society
Pages: - Volume / Issue: 87 (6) Sequence Number: - Start / End Page: 737 - 745 Identifier: ISSN: 0958-0670
CoNE: https://pure.mpg.de/cone/journals/resource/954927613928