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  Interactions between glutamate, dopamine, and the neuronal signature of response inhibition in the human striatum

Lorenz, R. C., Gleich, T., Buchert, R., Schlagenhauf, F., Kühn, S., & Gallinat, J. (2015). Interactions between glutamate, dopamine, and the neuronal signature of response inhibition in the human striatum. Human Brain Mapping, 36(10), 4031-4040. doi:10.1002/hbm.22895.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-6F22-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7BF8-C
Genre: Journal Article

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 Creators:
Lorenz, Robert C.1, 2, 3, Author
Gleich, Tobias1, 4, Author
Buchert, Ralph5, Author
Schlagenhauf, Florian1, 6, Author              
Kühn, Simone7, 8, Author
Gallinat, Jürgen1, 8, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
3Center for Adaptive Rationality, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
4NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
5Department of Nuclear Medicine, Charité University Medicine Berlin, Germany, ou_persistent22              
6Max Planck Fellow Group Cognitive and Affective Control of Behavioural Adaptation, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1753350              
7Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
8Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              

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Free keywords: Multimodal imaging; Dopamine; Glutamate; Striatum; Functional magnetic resonance imaging; Magnetic resonance spectroscopy; Positron emission tomography; Response inhibition
 Abstract: Response inhibition is a basic mechanism in cognitive control and dysfunctional in major psychiatric disorders. The neuronal mechanisms are in part driven by dopamine in the striatum. Animal data suggest a regulatory role of glutamate on the level of the striatum. We used a trimodal imaging procedure of the human striatum including F18-DOPA positron emission tomography, proton magnetic resonance spectroscopy, and functional magnetic resonance imaging of a stop signal task. We investigated dopamine synthesis capacity and glutamate concentration in vivo and their relation to functional properties of response inhibition. A mediation analysis revealed a significant positive association between dopamine synthesis capacity and inhibition-related neural activity in the caudate nucleus. This relationship was significantly mediated by striatal glutamate concentration. Furthermore, stop signal reaction time was inversely related to striatal activity during inhibition. The data show, for the first time in humans, an interaction between dopamine, glutamate, and the neural signature of response inhibition in the striatum. This finding stresses the importance of the dopamine–glutamate interaction for behavior and may facilitate the understanding of psychiatric disorders characterized by impaired response inhibition.

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Language(s): eng - English
 Dates: 2015-06-112015-02-092015-06-272015-07-142015-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.22895
PMID: 26177932
Other: Epub 2015
 Degree: -

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 36 (10) Sequence Number: - Start / End Page: 4031 - 4040 Identifier: ISSN: 1065-9471
CoNE: /journals/resource/954925601686