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  Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

Humphrey, S. J., James, D. E., & Mann, M. (2015). Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 26(12; Special Issue: Systems Approach to Metabolic Disease), 676-687. doi:10.1016/j.tem.2015.09.013.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-7295-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-7296-1
Genre: Journal Article

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 Creators:
Humphrey, Sean J.1, Author              
James, David E.2, Author
Mann, Matthias1, Author              
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
2external, ou_persistent22              

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Free keywords: GTPASE-ACTIVATING-PROTEIN; HEART 6-PHOSPHOFRUCTO-2-KINASE ACTIVATION; PHOSPHOPROTEOME REVEALS; QUANTITATIVE PROTEOMICS; TUBEROUS SCLEROSIS; IN-VIVO; INSULIN SENSITIVITY; SIGNALING DYNAMICS; MASS-SPECTROMETER; SKELETAL-MUSCLE
 Abstract: Metabolism research is undergoing a renaissance because many diseases are increasingly recognized as being characterized by perturbations in intracellular metabolic regulation. Metabolic changes can be conferred through changes to the expression of metabolic enzymes, the concentrations of substrates or products that govern reaction kinetics, or post-translational modification (PTM) of the proteins that facilitate these reactions. On the 60th anniversary since its discovery, reversible protein phosphorylation is widely appreciated as an essential PTM regulating metabolism. With the ability to quantitatively measure dynamic changes in protein phosphorylation on a global scale - hereafter referred to as phosphoproteomics - we are now entering a new era in metabolism research, with mass spectrometry (MS)-based proteomics at the helm.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: ISI: 000367025700004
DOI: 10.1016/j.tem.2015.09.013
 Degree: -

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Title: TRENDS IN ENDOCRINOLOGY AND METABOLISM
Source Genre: Journal
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Publ. Info: 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND : ELSEVIER SCIENCE LONDON
Pages: - Volume / Issue: 26 (12; Special Issue: Systems Approach to Metabolic Disease) Sequence Number: - Start / End Page: 676 - 687 Identifier: ISSN: 1043-2760