Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Agonist mobility on supported lipid bilayers affects Fas mediated death response

Sanchez, M. F., Levi, V., Weidemann, T., & Carrer, D. C. (2015). Agonist mobility on supported lipid bilayers affects Fas mediated death response. FEBS LETTERS, 589(23), 3527-3533. doi:10.1016/j.febslet.2015.10.009.

Item is

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Sanchez, M. Florencia1, Autor
Levi, Valeria1, Autor
Weidemann, Thomas2, Autor           
Carrer, Dolores C.1, Autor
Affiliations:
1external, ou_persistent22              
2Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565169              

Inhalt

einblenden:
ausblenden:
Schlagwörter: FLUORESCENCE CORRELATION SPECTROSCOPY; GIANT UNILAMELLAR VESICLES; IMMUNE-SYSTEM; PHOSPHOLIPID-BILAYERS; MEMBRANE DYNAMICS; CELL-ADHESION; ANNEXIN-V; APOPTOSIS; RECEPTOR; DIFFUSIONFluorescence correlation spectroscopy; Supported lipid bilayer; Apoptosis; Functionalized surface; Fas receptor;
 Zusammenfassung: Extrinsic apoptosis is initiated by recognition and clustering of the single-pass transmembrane proteins Fas ligand and Fas expressed at the surface of closely apposed lymphocytes and target cells, respectively. Since Fas-mediated death response was mainly studied with soluble antibodies, the mobility constraints for receptor activation by a membrane embedded agonist is not well understood. We explored this influence by stimulating apoptosis on functionalized supported lipid bilayers, where we quantified agonist mobility by z-scan fluorescence correlation spectroscopy. Using different lipid compositions, we show that the apoptotic response correlates with increased lateral mobility of the agonist in the lipid bilayer. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2015
 Publikationsstatus: Erschienen
 Seiten: 7
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000367232100004
DOI: 10.1016/j.febslet.2015.10.009
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: FEBS LETTERS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS : ELSEVIER SCIENCE BV
Seiten: - Band / Heft: 589 (23) Artikelnummer: - Start- / Endseite: 3527 - 3533 Identifikator: ISSN: 0014-5793