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  The information efficacy of a synapse

London, M., Schreibman, A., Häusser, M., Larkum, M. E., & Segev, I. (2002). The information efficacy of a synapse. Nature Neuroscience, 5(4), 332-340. doi:10.1038/nn826.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-711F-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-712C-A
Genre: Journal Article
Alternative Title : The information efficacy of a synapse

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NatNeurosci_5_2002_332.pdf (Any fulltext), 945KB
 
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http://www.nature.com/neuro/journal/v5/n4/pdf/nn826.pdf (Any fulltext)
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 Creators:
London, Michael, Author
Schreibman, Adi, Author
Häusser, Michael, Author
Larkum, Matthew E.1, Author           
Segev, Idan, Author
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: We provide a functional measure, the synaptic information efficacy (SIE), to assess the impact of synaptic input on spike output. SIE is the mutual information shared by the presynaptic input and postsynaptic output spike trains. To estimate SIE we used a method based on compression algorithms. This method detects the effect of a single synaptic input on the postsynaptic spike output in the presence of massive background synaptic activity in neuron models of progressively increasing realism. SIE increased with increases either in time locking between the input synapse activity and the output spike or in the average number of output spikes. SIE depended on the context in which the synapse operates. We also measured SIE experimentally. Systematic exploration of the effect of synaptic and dendritic parameters on the SIE offers a fresh look at the synapse as a communication device and a quantitative measure of how much the dendritic synapse informs the axon

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Language(s): eng - English
 Dates: 2001-12-172002-02-222002-03-182002-04
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666151
DOI: 10.1038/nn826
URI: http://www.ncbi.nlm.nih.gov/pubmed/11896396
URI: http://www.nature.com/neuro/journal/v5/n4/full/nn826.html
Other: 5201
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 5 (4) Sequence Number: - Start / End Page: 332 - 340 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931