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  Serum neuron-specific enolase is related to cerebellar connectivity: A resting-state functional magnetic resonance imaging pilot study

Schroeter, M. L., Mueller, K., Arélin, K., Sacher, J., Holiga, Š., Kratzsch, J., et al. (2015). Serum neuron-specific enolase is related to cerebellar connectivity: A resting-state functional magnetic resonance imaging pilot study. Journal of Neurotrauma, 32(17), 1380-1384. doi:10.1089/neu.2013.3163.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-7191-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-F3AA-A
Genre: Journal Article

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 Creators:
Schroeter, Matthias L.1, 2, 3, 4, Author              
Mueller, Karsten5, Author              
Arélin, Katrin1, 2, 3, Author              
Sacher, Julia1, 2, Author              
Holiga, Štefan3, 5, Author              
Kratzsch, Jürgen6, Author
Luck, Tobias3, 7, Author
Riedel-Heller, Steffi3, 7, Author
Villringer, Arno1, 2, 3, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
7Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              

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Free keywords: Connectivity; Neurons; Neuron-specific enolase; Neuropsychiatric disorders; Resting-state fMRI
 Abstract: Neuron-specific enolase (NSE) has been suggested as a prognostic biomarker for neuronal alterations resulting from conditions such as traumatic brain injury (TBI), neurodegenerative disease, or cardiac arrest. To validate serum NSE (sNSE) as a brain-specific biomarker, we related it to functional brain imaging data in 38 healthy adults to create a physiological framework for future studies in neuropsychiatric diseases. sNSE was measured by monoclonal two-site immunoluminometric assays, and functional connectivity was investigated with resting-state functional magnetic resonance imaging (rfMRI). To identify neural hubs most essentially related to sNSE, we applied graph theory approaches, namely, the new data‐driven and parameter‐free approach, eigenvector centrality mapping. sNSE and eigenvector centrality were negatively correlated in the female cerebellum, without any effects in male subjects. In cerebellar cortex, NSE expression was significantly higher than whole-brain expression as investigated in the whole brain and whole genome-wide atlas of the Allen Institute for Brain Sciences (Seattle, WA). Our study shows a specific linkage between the neuronal marker protein, sNSE, and cerebellar connectivity as measured with rfMRI in the female human brain, although this finding shall be proven in future studies including more subjects. Results suggest that the inclusion of sNSE in the analysis of imaging data is a useful approach to obtain more-specific information on the neuronal mechanisms that underlie functional connectivity at rest. Establishing such a baseline resting-state pattern that is tied to a neuronal serum marker opens new perspectives in the characterization of neuropsychiatric disorders as disconnective syndromes or nexopathies, in particular, resulting from TBI, neurodegenerative disease, or cardiac arrest, in the future.

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Language(s): eng - English
 Dates: 2015-05-262015-08-17
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1089/neu.2013.3163
PMID: 24844267
Other: Epub 2015
 Degree: -

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Title: Journal of Neurotrauma
  Other : J. Neurotrauma
Source Genre: Journal
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Affiliations:
Publ. Info: New York, NY : M.A. Liebert
Pages: - Volume / Issue: 32 (17) Sequence Number: - Start / End Page: 1380 - 1384 Identifier: ISSN: 0897-7151
CoNE: /journals/resource/954925561573