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  Components of a Mediterranean diet and their impact on cognitive functions in aging

Huhn, S., Kharabian, S., Stumvoll, M., Villringer, A., & Witte, V. (2015). Components of a Mediterranean diet and their impact on cognitive functions in aging. Frontiers in Aging Neuroscience, 7: 132. doi:10.3389/fnagi.2015.00132.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-7659-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-77FD-B
Genre: Journal Article

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 Creators:
Huhn, Sebastian1, Author              
Kharabian, Shahrzad1, Author              
Stumvoll, Michael2, 3, Author
Villringer, Arno1, 2, Author              
Witte, Veronica1, 2, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Cognition; Plasticity; Omega-3 fatty acids; Polyphenols; Resveratrol; Memory; Brain structure
 Abstract: Background: Adhering to the Mediterranean diet (MeDi) is known to be beneficial with regard to many age-associated diseases including cardiovascular diseases and type 2 diabetes. Recent studies also suggest an impact on cognition and brain structure, and increasing effort is made to track effects down to single nutrients. Aims: We aimed to review whether two MeDi components, i.e., long-chain omega-3 fatty acids (LC-n3-FA) derived from sea-fish, and plant polyphenols including resveratrol (RSV), exert positive effects on brain health in aging. Content: We summarized health benefits associated with the MeDi and evaluated available studies on the effect of (1) fish-consumption and LC-n3-FA supplementation as well as (2) diet-derived or supplementary polyphenols such as RSV, on cognitive performance and brain structure in animal models and human studies. Also, we discussed possible underlying mechanisms. Conclusion: A majority of available studies suggest that consumption of LC-n3-FA with fish or fishoil-supplements exerts positive effects on brain health and cognition in older humans. However, more large-scale randomized controlled trials are needed to draw definite recommendations. Considering polyphenols and RSV, only few controlled studies are available to date, yet the evidence based on animal research and first interventional human trials is promising and warrants further investigation. In addition, the concept of food synergy within the MeDi encourages future trials that evaluate the impact of comprehensive lifestyle patterns to help maintaining cognitive functions into old age.

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Language(s): eng - English
 Dates: 2015-05-202015-06-262015-07-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnagi.2015.00132
PMID: 26217224
PMC: PMC4495334
Other: eCollection 2015
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Title: Frontiers in Aging Neuroscience
  Abbreviation : Front Aging Neurosci
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Research Foundation
Pages: - Volume / Issue: 7 Sequence Number: 132 Start / End Page: - Identifier: ISSN: 1663-4365
CoNE: /journals/resource/1663-4365