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  Association of pain and CNS structural changes after spinal cord injury

Jutzeler, C. R., Huber, E., Callaghan, M. F., Luechinger, R., Curt, A., Kramer, J. L., et al. (2016). Association of pain and CNS structural changes after spinal cord injury. Scientific Reports, 6: 18534. doi:10.1038/srep18534.

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 Creators:
Jutzeler, Catherine R.1, Author
Huber, Eveline1, Author
Callaghan, Martina F.2, Author
Luechinger, Roger3, Author
Curt, Armin1, Author
Kramer, John L.K.1, 4, Author
Freund, Patrick1, 2, 5, 6, Author              
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
3Institute for Biomedical Engineering, University of Zurich, Switzerland, ou_persistent22              
4School if Kinesiology, Faculty of Education, University of British Columbia, Vancouver, BC, Canada, ou_persistent22              
5Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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 Abstract: Traumatic spinal cord injury (SCI) has been shown to trigger structural atrophic changes within the spinal cord and brain. However, the relationship between structural changes and magnitude of neuropathic pain (NP) remains incompletely understood. Voxel-wise analysis of anatomical magnetic resonance imaging data provided information on cross-sectional cervical cord area and volumetric brain changes in 30 individuals with chronic traumatic SCI and 31 healthy controls. Participants were clinically assessed including neurological examination and pain questionnaire. Compared to controls, individuals with SCI exhibited decreased cord area, reduced grey matter (GM) volumes in anterior cingulate cortex (ACC), left insula, left secondary somatosensory cortex, bilateral thalamus, and decreased white matter volumes in pyramids and left internal capsule. The presence of NP was related with smaller cord area, increased GM in left ACC and right M1, and decreased GM in right primary somatosensory cortex and thalamus. Greater GM volume in M1 was associated with amount of NP. Below-level NP-associated structural changes in the spinal cord and brain can be discerned from trauma-induced consequences of SCI. The directionality of these relationships reveals specific changes across the neuroaxis (i.e., atrophic changes versus increases in volume) and may provide substrates of underlying neural mechanisms in the development of NP.

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Language(s): eng - English
 Dates: 2015-04-222015-11-192016-01-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/srep18534
PMID: 26732942
PMC: PMC4702091
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 6 Sequence Number: 18534 Start / End Page: - Identifier: Other: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322