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  Volumetric and shape analysis of the thalamus and striatum in amnestic mild cognitive impairment

Leh, S. E., Kälin, A. M., Schroeder, C., Park, M. T. M., Chakravarty, M. M., Freund, P., et al. (2015). Volumetric and shape analysis of the thalamus and striatum in amnestic mild cognitive impairment. Journal of Alzheimer's Disease, 49(1), 237-249. doi:10.3233/JAD-150080.

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Leh, Sandra E.1, Author
Kälin, Andrea M.1, Author
Schroeder, Clemens1, Author
Park, Min Tae M.2, 3, Author
Chakravarty, M. Mallar2, 4, Author
Freund, Patrick5, 6, 7, 8, Author              
Gientl, Anton F.1, Author
Riese, Florian1, Author
Kollias, Spyros9, Author
Hock, Christoph1, Author
Michels, Lars9, Author
1Division of Psychiatry Research, Hospital for Psychogeriatric Medicine, University of Zurich, Switzerland, ou_persistent22              
2Cerebral Imaging Center, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
3Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, ou_persistent22              
4Institute of Biomedical Engineering, University of Montréal, QC, Canada, ou_persistent22              
5Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
6Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
7Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
8Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
9Department of Neuroradiology, University Hospital Zurich, Switzerland, ou_persistent22              


Free keywords: Alzheimer’s disease; cortical thickness; hippocampus; mild cognitive impairment; shape analysis; striatum; thalamus; volumetry
 Abstract: Alterations in brain structures, including progressive neurodegeneration, are a hallmark in patients with Alzheimer's disease (AD). However, pathological mechanisms, such as the accumulation of amyloid and the proliferation of tau, are thought to begin years, even decades, before the initial clinical manifestations of AD. In this study, we compare the brain anatomy of amnestic mild cognitive impairment patients (aMCI, n = 16) to healthy subjects (CS, n = 22) using cortical thickness, subcortical volume, and shape analysis, which we believe to be complimentary to volumetric measures. We were able to replicate "classical" cortical thickness alterations in aMCI in the hippocampus, amygdala, putamen, insula, and inferior temporal regions. Additionally, aMCI showed significant thalamic and striatal shape differences. We observed higher global amyloid deposition in aMCI, a significant correlation between striatal displacement and global amyloid, and an inverse correlation between executive function and right-hemispheric thalamic displacement. In contrast, no volumetric differences were detected in thalamic, striatal, and hippocampal regions. Our results provide new evidence for early subcortical neuroanatomical changes in patients with aMCI, which are linked to cognitive abilities and amyloid deposition. Hence, shape analysis may aid in the identification of structural biomarkers for identifying individuals at highest risk of conversion to AD.


Language(s): eng - English
 Dates: 2015-08-122015-09-21
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3233/JAD-150080
PMID: 26444755
 Degree: -



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Source 1

Title: Journal of Alzheimer's Disease
  Abbreviation : J. Alzheimers Dis.
Source Genre: Journal
Publ. Info: -
Pages: - Volume / Issue: 49 (1) Sequence Number: - Start / End Page: 237 - 249 Identifier: ISSN: 1387-2877
CoNE: https://pure.mpg.de/cone/journals/resource/1387-2877