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  Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease

Khan, M. M., Lustrino, D., Silveira, W. A., Wild, F., Straka, T., Issop, Y., et al. (2016). Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 113(3), 746-750. doi:10.1073/pnas.1524272113.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-7760-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-78B3-6
Genre: Journal Article

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 Creators:
Khan, Muzamil Majid, Author
Lustrino, Danilo, Author
Silveira, Willian A., Author
Wild, Franziska, Author
Straka, Tatjana, Author
Issop, Yasmin, Author
O’Connor, Emily, Author
Cox, Dan, Author
Reischl, Markus, Author
Marquardt, Till, Author
Labeit, Dittmar, Author
Labeit, Siegfried, Author
Benoit, Evelyne, Author
Molgó, Jordi, Author
Lochmüller, Hanns, Author
Witzemann, Veit1, Author              
Kettelhut, Isis C., Author
Navegantes, Luiz C. C., Author
Pozzan, Tullio, Author
Rudolf, Rüdiger, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: beta-agonists; cAMP; myasthenia; neuromuscular junction; sympathetic neurons
 Abstract: The distribution and function of sympathetic innervation in skeletal muscle have largely remained elusive. Here we demonstrate that sympathetic neurons make close contact with neuromuscular junctions and form a network in skeletal muscle that may functionally couple different targets including blood vessels, motor neurons, and muscle fibers. Direct stimulation of sympathetic neurons led to activation of muscle postsynaptic β2-adrenoreceptor (ADRB2), cAMP production, and import of the transcriptional coactivator peroxisome proliferator-activated receptor γ-coactivator 1α (PPARGC1A) into myonuclei. Electrophysiological and morphological deficits of neuromuscular junctions upon sympathectomy and in myasthenic mice were rescued by sympathicomimetic treatment. In conclusion, this study identifies the neuromuscular junction as a target of the sympathetic nervous system and shows that sympathetic input is crucial for synapse maintenance and function.

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Language(s): eng - English
 Dates: 2015-11-102016-01-052016-01-052016-01-19
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 113 (3) Sequence Number: - Start / End Page: 746 - 750 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230