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  Dissociation of amyloid biomarkers in PET and CSF in Alzheimer’s disease: A case report

Schroeter, M. L., Tiepolt, S., Marschhauser, A., Thöne-Otto, A., Hoffmann, K.-T., Barthel, H., et al. (2015). Dissociation of amyloid biomarkers in PET and CSF in Alzheimer’s disease: A case report. BMC Neurology, 15: 152. doi:10.1186/s12883-015-0410-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-7783-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7679-1
Genre: Journal Article

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Schroeter_Tiepolt_2015.pdf (Publisher version), 791KB
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 Creators:
Schroeter, Matthias L.1, 2, 3, 4, Author              
Tiepolt, Solveig5, Author
Marschhauser, Anke2, Author
Thöne-Otto, Angelika2, Author
Hoffmann, Karl-Titus6, Author
Barthel, Henryk5, Author
Obrig, Hellmuth1, 2, Author              
Sabri, Osama5, Author
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              
5Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
6Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Alzheimer’s disease; Amyloid; CSF; MRI; PET
 Abstract: Background Recently, biomarkers have been suggested to be incorporated into diagnostic criteria for Alzheimer’s disease (AD). Regarding disease-specific brain amyloid-beta deposition these comprise low amyloid-beta 1–42 in cerebrospinal fluid (CSF) and positive positron emission tomography (PET) amyloid imaging, while neuronal degeneration is evidenced by high total and phosphorylated tau levels in CSF (t-/p-tau), regional hypometabolism ([18F]fluorodeoxyglucose PET, FDG-PET) and characteristic atrophy-patterns (magnetic resonance imaging, MRI). Case presentation Here we present a case of clinically and biomarker supported AD (CSF t-/p-tau, MRI, FDG-PET) in a 59-year-old Caucasian man in whom indicators of amyloid-beta deposition dissociated between CSF parameters and the respective PET imaging. Conclusions Such cases highlight the necessity to better understand potential dissociations between PET and CSF data for amyloid-beta biomarkers, because they are currently considered interchangeably valid with regard to in-vivo evidence for AD pathology. This is more important since amyloid deposition markers can be considered a very first prognostic indicator of imminent AD, prior to neurodegenerative biomarkers and cognitive symptoms. The case illustrates the need for further longitudinal data on potential dissociations of AD biomarkers to devise recommendations for their better prognostic and diagnostic interpretation in the future.

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Language(s): eng - English
 Dates: 2015-01-052015-08-142015-08-26
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1186/s12883-015-0410-5
PMID: 26303364
PMC: PMC4548309
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Title: BMC Neurology
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: - Volume / Issue: 15 Sequence Number: 152 Start / End Page: - Identifier: ISSN: 1471-2377
CoNE: /journals/resource/111032787578006