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  Structure of the functional domain of the major grass-pollen allergen Phlp 5b

Rajashankar, K., Bufe, A., Weber, W., Eschenburg, S., Lindner, B., & Betzel, C. (2002). Structure of the functional domain of the major grass-pollen allergen Phlp 5b. Acta Crystallographica Section D-Biological Crystallography, 58(7), 1175-1181. doi:10.1107/S0907444902007254.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-7829-B Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0029-782A-9
Genre: Journal Article
Alternative Title : Structure of the functional domain of the major grass-pollen allergen Phlp 5b

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 Creators:
Rajashankar, Kanagalaghatta, Author
Bufe, Albrecht, Author
Weber, Wolfgang, Author
Eschenburg, Susanne1, Author           
Lindner, Buko, Author
Betzel, Christian, Author
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

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Free keywords: pollen allergen; functional domain; SIRAS
 Abstract: The major allergen Phlp 5b from timothy grass pollen induces allergic rhinitis and bronchial asthma in millions of allergic patients worldwide. As an important step towards understanding the interactions between the pollen protein and components of the human immune system, the structure of the C-terminal key domain of Phlp 5b has been determined at 2.0 A resolution and refined to an R value of 19.7%. This is the first known allergen composed entirely of alpha-helices. The protein forms a dimer stabilized by one intermolecular disulfide bridge. Sequence homology suggests that at least all group V and group VI grass-pollen allergens belong to this new class of 'four-helix-bundle allergens'.

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Language(s): eng - English
 Dates: 2001-11-292002-04-192002-05-202002-07
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 666143
DOI: 10.1107/S0907444902007254
URI: http://www.ncbi.nlm.nih.gov/pubmed/12077438?dopt%3DAbstract
URI: http://journals.iucr.org/d/issues/2002/07/00/en0059/index.html
Other: 5234
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Title: Acta Crystallographica Section D-Biological Crystallography
Source Genre: Journal
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Publ. Info: [Copenhagen, Denmark : Published for the International Union of Crystallography by Munksgaard]
Pages: - Volume / Issue: 58 (7) Sequence Number: - Start / End Page: 1175 - 1181 Identifier: ISSN: 0907-4449
CoNE: https://pure.mpg.de/cone/journals/resource/954925562619_1