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  Simple peptide-tuned self-assembly of photosensitizers towards anticancer photodynamic therapy

Liu, K., Xing, R., Zou, Q., Ma, G., Möhwald, H., & Yan, X. (2016). Simple peptide-tuned self-assembly of photosensitizers towards anticancer photodynamic therapy. Angewandte Chemie International Edition, 55(9), 3036-3039. doi:10.1002/anie.201509810.

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 Creators:
Liu, Kai, Author
Xing, Ruirui, Author
Zou, Qianli1, Author
Ma, Guanghui, Author
Möhwald, Helmuth1, Author           
Yan, Xuehai, Author
Affiliations:
1Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863284              

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Free keywords: cooperative self-assembly, nanodrugs, peptides, photodynamic therapy, photosensitizers
 Abstract: Peptide-tuned self-assembly of functional components offers a strategy towards improved properties and unique functions of materials, but the requirement of many different functions and a lack of understanding of complex structures present a high barrier for applications. Herein, we report a photosensitive drug delivery system for photodynamic therapy (PDT) by a simple dipeptide- or amphiphilic amino-acid-tuned self-assembly of photosensitizers (PSs). The assembled nanodrugs exhibit multiple favorable therapeutic features, including tunable size, high loading efficiency, and on-demand drug release responding to pH, surfactant, and enzyme stimuli, as well as preferable cellular uptake and biodistribution. These features result in greatly enhanced PDT efficacy in vitro and in vivo, leading to almost complete tumor eradication in mice receiving a single drug dose and a single exposure to light.

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 Dates: 2016-01-252016
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/anie.201509810
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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 55 (9) Sequence Number: - Start / End Page: 3036 - 3039 Identifier: ISSN: 1433-7851