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  Disturbed cortico–amygdalar functional connectivity as pathophysiological correlate of working memory deficits in bipolar affective disorder

Stegmayer, K., Usher, J., Trost, S., Henseler, I., Tost, H., Rietschel, M., et al. (2015). Disturbed cortico–amygdalar functional connectivity as pathophysiological correlate of working memory deficits in bipolar affective disorder. European Archives of Psychiatry and Clinical Neuroscience, 265(4), 303-311. doi:10.1007/s00406-014-0517-5.

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 Creators:
Stegmayer, Katharina1, Author
Usher, Juliana2, Author
Trost, Sarah2, Author
Henseler, Ilona3, Author              
Tost, Heike4, Author
Rietschel, Marcella4, Author
Falkai, Peter5, Author
Gruber, Oliver2, Author
Affiliations:
1University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland, ou_persistent22              
2Centre for Translational Research in Systems Neuroscience and Psychiatry, University Medical Center, Göttingen, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Central Institute of Mental Health, Mannheim, Germany, ou_persistent22              
5Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany, ou_persistent22              

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Free keywords: Amygdala; Functional coupling; Functional magnetic resonance imaging; Limbic system; Euthymia
 Abstract: Patients suffering from bipolar affective disorder show deficits in working memory functions. In a previous functional magnetic resonance imaging study, we observed an abnormal hyperactivity of the amygdala in bipolar patients during articulatory rehearsal in verbal working memory. In the present study, we investigated the dynamic neurofunctional interactions between the right amygdala and the brain systems that underlie verbal working memory in both bipolar patients and healthy controls. In total, 18 euthymic bipolar patients and 18 healthy controls performed a modified version of the Sternberg item-recognition (working memory) task. We used the psychophysiological interaction approach in order to assess functional connectivity between the right amygdala and the brain regions involved in verbal working memory. In healthy subjects, we found significant negative functional interactions between the right amygdala and multiple cortical brain areas involved in verbal working memory. In comparison with the healthy control subjects, bipolar patients exhibited significantly reduced functional interactions of the right amygdala particularly with the right-hemispheric, i.e., ipsilateral, cortical regions supporting verbal working memory. Together with our previous finding of amygdala hyperactivity in bipolar patients during verbal rehearsal, the present results suggest that a disturbed right-hemispheric “cognitive–emotional” interaction between the amygdala and cortical brain regions underlying working memory may be responsible for amygdala hyperactivation and affects verbal working memory (deficits) in bipolar patients.

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Language(s): eng - English
 Dates: 2013-12-252014-07-232014-08-142015-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00406-014-0517-5
PMID: 25119145
Other: Epub 2014
 Degree: -

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Title: European Archives of Psychiatry and Clinical Neuroscience
Source Genre: Journal
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Publ. Info: Berlin : Springer International
Pages: - Volume / Issue: 265 (4) Sequence Number: - Start / End Page: 303 - 311 Identifier: ISSN: 0940-1334
CoNE: https://pure.mpg.de/cone/journals/resource/954927622119