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  Baseline oxygenation in the brain: Correlation between respiratory-calibration and susceptibility methods

Fan, A. P., Schäfer, A., Huber, L., Lampe, L., von Smuda, S., Möller, H. E., et al. (2016). Baseline oxygenation in the brain: Correlation between respiratory-calibration and susceptibility methods. NeuroImage, 125, 920-931. doi:10.1016/j.neuroimage.2015.11.007.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-79E5-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1A73-F
Genre: Journal Article

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 Creators:
Fan, Audrey P.1, 2, Author
Schäfer, Andreas1, Author              
Huber, Laurentius3, Author              
Lampe, Leonie4, Author              
von Smuda, Steffen3, Author              
Möller, Harald E.3, Author              
Villringer, Arno4, Author              
Gauthier, Claudine4, 5, Author              
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
2Richard M. Lucas Service Center for Imaging, Stanford University, CA, USA, ou_persistent22              
3Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Concordia University, Montréal, QC, Canada, ou_persistent22              

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Free keywords: Brain oxygenation; Oxygen extraction fraction; Quantitative susceptibility mapping; Calibrated BOLD; Magnetic resonance imaging
 Abstract: New MRI methods for noninvasive imaging of baseline oxygen extraction fraction (OEF) in the brain show great promise. Quantitative O2 imaging (QUO2) applies a biophysical model to measure OEF in tissue from BOLD, cerebral blood flow (CBF), and end-tidal O2 (ETO2) signals acquired during two or more gas manipulations. Alternatively, quantitative susceptibility mapping (QSM) maps baseline OEF along cerebral vessels based on the deoxyhemoblogin (dHb) susceptibility shift between veins and water. However, these approaches have not been carefully compared to each other or to known physiological signals. The aims of this study were to compare OEF values by QUO2 and QSM; and to see if baseline OEF relates to BOLD and CBF changes during a visual task. Simultaneous BOLD and arterial spin labeling (ASL) scans were acquired at 7 T in 11 healthy subjects continuously during hypercapnia (5% CO2, 21% O2), hyperoxia (100% O2), and carbogen (5% CO2, 95% O2) for QUO2 analysis. Separate BOLD-ASL scans were acquired during a checkerboard stimulus to identify functional changes in the visual cortex. Gradient echo phase images were also collected at rest for QSM reconstruction of OEF along cerebral veins draining the visual cortex. Mean baseline OEF was (43.5 ± 14)% for QUO2 with two gases, (42.3 ± 17)% for QUO2 with three gases, and (29.4 ± 3)% for QSM across volunteers. Three-gas QUO2 values of OEF correlated with QSM values of OEF (P = 0.03). However, Bland–Altman analysis revealed that QUO2 tended to measure higher baseline OEF with respect to QSM, which likely results from underestimation of the hyperoxic BOLD signal and low signal-to-noise ratio of the ASL acquisitions. Across subjects, the percent CBF change during the visual task correlated with OEF measured by 3-gas QUO2 (P < 0.04); and by QSM (P = 0.035), providing evidence that the new methods measure true variations in brain physiology across subjects.

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Language(s): eng - English
 Dates: 2015-07-102015-11-032015-11-052016-01-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2015.11.007
PMID: 26549301
Other: Epub 2015
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 125 Sequence Number: - Start / End Page: 920 - 931 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166